Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats
Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats
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DOI：
10.1152/ajpheart.1997.272.3.h1412
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发表时间：
1997-03-01
影响因子：
4.8
通讯作者：
DiCarlo, SE
中科院分区：
文献类型：
--
作者：
Chen, YF;Chandler, MP;DiCarlo, SE
日常运动和性别对高血压大鼠运动后心脏自主神经反应的影响。上午好。J.Physiol.272(心圈。物理。41)：H1412-H1418,1997。-研究了自发性高血压大鼠每日自发跑步(DSR)和性别对运动后心脏自主神经反应的影响。大鼠于4~5周龄断奶，随机分为久坐组(7男6女)和DSR组(7男8女)。在DSR或静坐对照8周后，用动脉和静脉导管对大鼠进行慢性内固定。恢复5天后，在不运动和运动后两种实验条件下隔天测定心脏交感神经(ST)和副交感神经张力(PT)(通过心率对受体拮抗剂的反应)。在单次动态跑步机运动(12m/min，10%等级40min)后，ST降低(P<；0.05)(男性久坐：不运动45+/-4次/分钟，运动后28+/-3次/分钟；女性：不运动69+/-10次/分钟，运动后37+/-7次/分钟)。运动后PT也发生改变(男性久坐：不运动-31+/-4次，运动后-11+/-2次/分钟；女性久坐：不运动-5+/-4次/分钟，运动后7+/-4次/分钟)。DSR治疗后ST降低(男性久坐45+/-4vs.DSR22+/-3次/min；女性69+/-10vs.DSR36+/-4次/min)(P<；0.05)。雄鼠的ST低于雌鼠，PT高于雌鼠。这些结果表明：1)单次动态运动后ST降低，2)DSR后ST降低，3)DSR后自主神经反应减弱，4)性别对心脏自主神经功能的影响。
Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H1412-H1418, 1997.-The influence of daily spontaneous running (DSR) and gender on postexercise cardiac autonomic responses was examined in spontaneously hypertensive rats. Rats were weaned at 4-5 wk of age and were randomly assigned to a sedentary (7 males and 6 females) or DSR (7 males and 8 females) group. After 8 weeks of DSR or sedentary control, rats were chronically instrumented with arterial and venous catheters. After 5 days of recovery, cardiac sympathetic (ST) and parasympathetic tonus (PT) were determined (by the response of heart rate to receptor antagonists) on alternate days under two experimental conditions: no exercise and postexercise. After a single bout of dynamic treadmill exercise (12 m/min, 10% grade for 40 min) ST was reduced (P < 0.05) (male sedentary: no exercise 45 +/- 4 vs. postexercise 28 +/- 3 beats/min; female sedentary: no exercise 69 +/- 10 vs. postexercise 37 +/- 7 beats/ min). PT was also altered after exercise (male sedentary: no exercise -31 +/- 4 vs. postexercise -11 +/- 2 beats/min; female sedentary: no exercise -5 +/- 4 vs. postexercise 7 +/- 4 beats/ min). After DSR, ST was reduced (male sedentary 45 +/- 4 vs. DSR 22 +/- 3 beats/min; female sedentary 69 +/- 10 vs. DSR 36 +/- 4 beats/min) (P < 0.05). Finally, male rats had a lower ST and higher PT than female rats. These results demonstrate that I) ST was reduced after a single bout of dynamic exercise; 2) ST was reduced after DSR; 3) the autonomic response to acute exercise was attenuated after DSR; and 4) there was a gender influence on the cardiac autonomic function.