INFLUENCE OF OXYTOCIN ON FEEDING-BEHAVIOR IN THE RAT
INFLUENCE OF OXYTOCIN ON FEEDING-BEHAVIOR IN THE RAT
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DOI：
10.1016/0196-9781(89)90082-x
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发表时间：
1989-01-01
期刊：
影响因子：
3
通讯作者：
BERTOLINI, A
中科院分区：
文献类型：
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作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
无论是腹膜内注射催产素(375-6,000微克/公斤)还是脑室注射催产素(1-10微克/只)，禁食21小时的大鼠均可剂量依赖性地减少食物消耗和进食时间，并延长第一餐的潜伏期。预先给予催产素拮抗剂d(CH2)5Tyr(Me)-[Orn8]Vasotoin(icv10微克/只)可完全阻断等剂量icv催产素的摄食抑制作用，并增加摄食量。我们的数据进一步支持了催产素在中枢神经系统中扮演神经调节剂神经递质的角色的假说，并表明它可能参与了许多动态平衡系统，包括食欲控制。
Oxytocin, whether administered intraperitoneally (IP) (375-6,000 .mu.g/kg) or intracerebroventricularly (ICV) (1-10 .mu.g/rat), dose-dependently reduced food consumption and time spent eating and increased the latency to the first meal in rats fasted for 21 hr. Pretreatment with the oxytocin antagonist d(CH2)5Tyr(Me)-[Orn8]vasotocin (ICV 10 .mu.g/rat) completely prevented the feeding inhibitory effect of an equal dose of ICV oxytocin, and per se increased food intake. Our data further support the hypothesis that oxytocin plasy the role of neurotransmitter of neuromodulator in the CNS, and suggest that its involvement in a number of homeostatic systems may include appetite control.