The role of monocyte chemoattractant protein-1 in biliary atresia
The role of monocyte chemoattractant protein-1 in biliary atresia
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DOI：
10.1016/j.jpedsurg.2006.08.018
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
Miyano, Takeshi
中科院分区：
文献类型：
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作者：
Kobayashi, Hiroyuki;Tamatani, Takuya;Miyano, Takeshi
背景资料：为探讨单核细胞趋化蛋白-1（MCP-1）在胆道闭锁（BA）中的作用，采用试剂盒检测38例BA患者血清MCP-1和IV型胶原的浓度。MCP-1也通过使用免疫组织化学在肝活检标本中进行评估。受试者被分成不同的组。I组包括肝功能正常的BA患者（n = 13），II组包括中度肝功能障碍的BA患者（n = 18），III组包括等待肝移植的年龄大于20年的BA患者（n = 7），对照组包括年龄匹配的无肝病证据的患者（n = 23）。与I组相比，II组血清MCP-1水平显著升高（P
Background: The aim of this study was to explain the role of monocyte chemoattractant protein-1 (MCP-1) in biliary atresia (BA).Methods: Concentrations of serum MCP-1 and collagen type IV were measured in 38 patients with BA by using commercially available kits. MCP-1 was also assessed in liver biopsy specimens by using immumohistochemistry. Subjects were classified into groups. Group I comprised BA patients with normal liver function (n = 13), group II comprised BA patients with moderate liver dysfunction (n = 18), group III comprised BA patients older than 20 years awaiting liver transplantation (n = 7), and the control group comprised age-matched patients without evidence of liver disease (n = 23).Results: Serum MCP-1 levels were significantly increased in group II compared with group I (P