Impact of FDG-PET on lung cancer delineation for radiotherapy
Impact of FDG-PET on lung cancer delineation for radiotherapy
复制标题
DOI：
10.1111/j.1754-9485.2012.02356.x
复制
发表时间：
2012-04-01
影响因子：
1.6
通讯作者：
Laurence, Jerome M.
中科院分区：
文献类型：
--
作者：
Morarji, Kavita;Fowler, Allan;Laurence, Jerome M.
目的：评价融合诊断F-18 2-氟-2-脱氧-D-葡萄糖(FDG)正电子发射断层扫描(PET)/CT扫描和计划FDG-PET/CT扫描对肺癌放射治疗体积的影响。单独使用CT、诊断FDG-PET/CT和计划FDG-PET/CT分别注册到CT，以勾画出三个体积。使用一致性指数(CI)将每个体积与参考RO值进行比较。结果：尽管CT等高线在观察者间有相当大的变异性，但使用任何技术的RO和放射肿瘤学实习生的平均肿瘤体积之间没有显著差异。对于RO，无论是诊断性的还是计划性的，增加了PET/CT检查，CI都没有增加。然而，放射肿瘤学实习生的CI从单纯CT的65.8%显著增加到诊断性和计划性PET/CT的68.0%和72.3%(P=0.028)。肿瘤/纵隔交界处的平均变异随着登记的PET/CT的加入而显著减小。结论：使用整合的FDG PET/CT图像，RO与参考RO的符合率没有显著增加。然而，放射肿瘤学实习生的轮廓与参考变得更加一致。
Purpose: The purpose of this study is to assess the impact of fused diagnostic F-18 2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) and planning FDG-PET/CT scans on voluming of lung cancer for radiotherapy.Methods: Five radiation oncologists (ROs), five radiation oncology trainees and a radiologist contoured five cases of non-small cell lung cancer. The CT alone, the diagnostic FDG-PET/CT and planning FDG-PET/CT each registered to the CT, were used to contour three volumes. The concordance index (CI) was used to compare each volume with a reference RO.Results: Although there was considerable inter-observer variability in CT contouring, there was no significant difference between mean volumes of the gross tumour volume for the RO and radiation oncology trainees using any technique. There was no increase in CI with the addition of PET/CT, either diagnostic or planning, for the RO. However, the volumes of the radiation oncology trainees showed a significant increase in CI from 65.8% with CT alone to 68.0% and 72.3% with diagnostic PET/CT and planning PET/CT, respectively (P = 0.028). Mean variation at the tumour/mediastinum interface was significantly reduced with addition of registered PET/CT.Conclusions: The concordance of RO with the reference RO did not significantly increase with use of integrated FDG PET/CT images. However, the contouring of radiation oncology trainees' became more concordant with the reference.