APOE ε4 differentially influences change in memory performance depending on age. The SMART-MR study
APOE ε4 differentially influences change in memory performance depending on age. The SMART-MR study
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DOI：
10.1016/j.neurobiolaging.2011.07.016
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发表时间：
2012-04-01
影响因子：
4.2
通讯作者：
Geerlings, Mirjam I.
中科院分区：
文献类型：
--
作者：
Jochemsen, Hadassa M.;Muller, Majon;Geerlings, Mirjam I.
载脂蛋白E（APOE）基因在年轻人和老年人中的作用可能不同，称为拮抗性多效性。因此，我们在SMART-MR（ARTerial disease的第二表现-磁共振）队列研究中，对375名非痴呆成年人（平均年龄57 ± 10岁;随访期3.8 ± 0.2年）的APOE基因型和认知功能的可用数据进行了前瞻性研究，以探讨APOE β 4等位基因和认知功能之间的前瞻性相关性，以及年龄的修饰效应。在基线和随访时进行神经心理学测试，评估记忆表现和执行功能，并计算复合z分数。年龄显著改变了APOE β 4与记忆表现变化的相关性（p交互作用= 0.02）。在年龄<57岁的人群中，APOE β 4等位基因与即刻回忆下降相关（B = -0.25; 95% CI，-0.52至0.01）。我们的研究结果表明，载脂蛋白E β 4等位基因有不同的影响，在言语记忆性能的变化取决于年龄，与拮抗多效性的假说一致。(C)2012 Elsevier Inc. All rights reserved.
The apolipoprotein E (APOE) gene may act differently in young and old persons, known as antagonistic pleiotropy. We therefore examined the prospective associations between the APOE epsilon 4 allele and cognitive functioning, and the modifying effect of age, in 375 nondemented adults (mean age 57 +/- 10 years; follow-up period 3.8 +/- 0.2 years) with available data on APOE genotype and cognitive functioning, within the SMART-MR (Second Manifestations of ARTerial disease-Magnetic Resonance) cohort study. Neuropsychological tests assessing memory performance and executive functioning were performed at baseline and follow-up, and composite z-scores were calculated. Age significantly modified the association of APOE epsilon 4 with change in memory performance (p interaction = 0.02). In persons 57 years, an APOE epsilon 4 allele was associated with decline in immediate recall (B = -0.25; 95% CI, -0.52 to 0.01). Our findings suggest that the APOE epsilon 4 allele has a differential effect on change in verbal memory performance depending on age, consistent with the hypothesis of antagonistic pleiotropy. (C) 2012 Elsevier Inc. All rights reserved.