Profiling of plasma metabolites in postmenopausal women with metabolic syndrome.
Profiling of plasma metabolites in postmenopausal women with metabolic syndrome.
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DOI：
10.1097/gme.0000000000000630
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Takebayashi T
中科院分区：
文献类型：
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作者：
Iida M;Harada S;Kurihara A;Fukai K;Kuwabara K;Sugiyama D;Takeuchi A;Okamura T;Akiyama M;Nishiwaki Y;Suzuki A;Hirayama A;Sugimoto M;Soga T;Tomita M;Banno K;Aoki D;Takebayashi T
该研究的目的是调查氨基酸和其他极性代谢物与瘦亚洲人群绝经后女性代谢综合征 (MetS) 的关系。参与者是 2012 年 4 月至 8 月参加队列研究的 1,422 名女性居民。MetS 的定义是根据针对日本女性修改的国家胆固醇教育计划成人治疗小组 III 进行的。使用毛细管电泳-质谱法检查了 MetS 与空腹血浆样本中测定的 78 种代谢物之间的关联。进行复制分析以确认随机分配创建的单独群体中结果的稳健性。对 877 名自然绝经后的女性进行了分析，其中 594 名来自原始人群，283 名来自复制人群。全体人群的平均年龄、体重指数和高密度脂蛋白胆固醇水平分别为23.0kg/m2、72.1mg/dL和126.1mg/dL。患有和不患有 MetS 的女性之间的低密度脂蛋白胆固醇水平没有显着差异。有 13 种代谢物与 MetS 显着相关：患有 MetS 的女性多种血浆氨基酸升高，包括支链氨基酸、丙氨酸、谷氨酸和脯氨酸；赖氨酸降解产生的α-氨基己二酸也显着增加。我们的大规模代谢组学分析表明，患有 MetS 的日本绝经后女性具有异常的极性代谢物，表明分解代谢途径发生了改变。这些结果可能有助于了解代谢紊乱，包括体重指数正常和高密度脂蛋白胆固醇水平相对较高的人，并且基于进一步的研究可能具有临床实用性。
The aim of the study was to investigate the associations of amino acids and other polar metabolites with metabolic syndrome (MetS) in postmenopausal women in a lean Asian population. The participants were 1,422 female residents enrolled in a cohort study from April to August 2012. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for Japanese women. Associations were examined between MetS and 78 metabolites assayed in fasting plasma samples using capillary electrophoresis-mass spectrometry. Replication analysis was performed to confirm the robustness of the results in a separate population created by random allocation. Analysis was performed for 877 naturally postmenopausal women, including 594 in the original population and 283 in the replication population. The average age, body mass index, and levels of high- and low-density lipoprotein cholesterol of the entire population were 64.6 years, 23.0 kg/m2, 72.1 mg/dL, and 126.1 mg/dL, respectively. There was no significant difference in low-density lipoprotein cholesterol levels between women with and without MetS. Thirteen metabolites were significantly related to MetS: multiple plasma amino acids were elevated in women with MetS, including branched-chain amino acids, alanine, glutamate, and proline; and alpha-aminoadipate, which is generated by lysine degradation, was also significantly increased. Our large-scale metabolomic profiling indicates that Japanese postmenopausal women with MetS have abnormal polar metabolites, suggesting altered catabolic pathways. These results may help to understand metabolic disturbance, including in persons with normal body mass index and relatively high levels of high-density lipoprotein cholesterol, and may have clinical utility based on further studies.