A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide
A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide
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DOI：
10.1021/ja0444029
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发表时间：
2005-03-23
影响因子：
15
通讯作者：
Ungaro, R
中科院分区：
文献类型：
--
作者：
Arosio, D;Fontanella, M;Ungaro, R
一种霍乱毒素的高亲和力配体，二价糖杯[4]芳烃，是通过利用基于结构的拟糖单价配体的设计和通过杯[4]芳烃支架的多价呈现来增强亲和力而获得的。它对毒素的亲和力略高于其天然配体GM1寡糖。
A high-affinity ligand of cholera toxin, the divalent glycocalix[4]arene1, was obtained by exploiting a combination of structure-based design of glycomimetic monovalent ligands and affinity enhancements by multivalent presentation through a calix[4]arene scaffold. It exhibits a slightly higher affinity for the toxin than its natural ligand, the GM1 oligosaccharide.