CoDNaS 2.0: a comprehensive database of protein conformational diversity in the native state
CoDNaS 2.0: a comprehensive database of protein conformational diversity in the native state
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DOI：
10.1093/database/baw038
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发表时间：
2016-03-28
影响因子：
5.8
通讯作者：
Parisi, Gustavo
中科院分区：
文献类型：
--
作者：
Miguel Monzon, Alexander;Oscar Rohr, Cristian;Parisi, Gustavo
CoDNAS（conformational diversity of the native state）是一个蛋白质构象多样性数据库。构象多样性描述了定义蛋白质天然状态的构象异构体之间的结构差异。它是理解蛋白质功能和与蛋白质功能相关的生物学过程的关键概念。CoDNaS提供了一个精心策划的数据库，它是实验驱动的，完全链接和注释的。CoDNAS有助于提取基于蛋白质运动的小结构差异的关键信息。CoDNAS使用户能够轻松地将构象多样性的程度与蛋白质结构和生物学特性实验中获得的物理，化学和生物学特性联系起来。新版本的CoDNAS包含了所有可用蛋白质结构的70%，并且增加了新的工具，可以运行序列搜索，显示结构灵活性概况，并允许用户浏览数据库以获得不同的结构类别。这些工具有助于探索蛋白质构象多样性及其在蛋白质功能中的作用。
CoDNaS (conformational diversity of the native state) is a protein conformational diversity database. Conformational diversity describes structural differences between conformers that define the native state of proteins. It is a key concept to understand protein function and biological processes related to protein functions. CoDNaS offers a well curated database that is experimentally driven, thoroughly linked, and annotated. CoDNaS facilitates the extraction of key information on small structural differences based on protein movements. CoDNaS enables users to easily relate the degree of conformational diversity with physical, chemical and biological properties derived from experiments on protein structure and biological characteristics. The new version of CoDNaS includes similar to 70% of all available protein structures, and new tools have been added that run sequence searches, display structural flexibility profiles and allow users to browse the database for different structural classes. These tools facilitate the exploration of protein conformational diversity and its role in protein function.