Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound.
Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound.
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DOI：
10.3928/1081597x-20150623-01
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Silverman RH
中科院分区：
文献类型：
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作者：
Reinstein DZ;Yap TE;Archer TJ;Gobbe M;Silverman RH
比较光学相干断层扫描（OCT）和甚高频数字超声（VHFDU）测量角膜上皮厚度。回顾性分析使用RTVue傅里叶域OCT (Optovue, Inc., Fremont， CA)（包括泪膜）和Artemis VHFDU (ArcScan Inc., Morrison， CO)（不包括泪膜）测量角膜上皮厚度的189例处女角膜和175例激光屈光手术（LRS）后角膜。计算了中心2毫米直径区域和另外两个1.5和0.5毫米宽度的同心环空的平均值，每个环空分为8个扇区。采用平均差（OCT - VHFDU）、95%一致限（LoA）（差值1.96标准差）和Bland-Altman分析进行一致性分析。在原始上皮中，OCT的平均中心厚度为53.4±3.20 μm（范围：46 ~ 62 μm）， VHFDU的平均中心厚度为54.1±2.96 μm（范围：48 ~ 61 μm）；OCT最薄70%，平均差为- 0.71 μm （95% LoA为±3.94 μm, P < 0.001）。lrs后，OCT组平均中心厚度为57.9±6.08 μm（范围42 ~ 77 μm）， VHFDU组平均中心厚度为60.5±6.47 μm（范围42 ~ 79 μm）；OCT最薄（88%），平均差为−2.48 μm （95% LoA为±5.33 μm, P < 0.001）。两种方法之间的较大差异在较厚的上皮中更为常见。使用OCT测量角膜上皮厚度发现比VHFDU略薄。与VHFDU相比，OCT测量包括撕裂膜，因此真实差异可能比报道的大约4 μm。在lrs后眼和较厚的上皮中，差异最大。
To compare measurements of corneal epithelial thickness using optical coherence tomography (OCT) and very high-frequency digital ultrasound (VHFDU). Retrospective analysis of 189 virgin corneas and 175 post-laser refractive surgery (LRS) corneas that had corneal epithelial thickness measurement with RTVue Fourier-domain OCT (Optovue, Inc., Fremont, CA) (tear film included) and Artemis VHFDU (ArcScan Inc., Morrison, CO) (tear film excluded). Averages were calculated for the central 2-mm diameter zone and for two further concentric annuli of 1.5- and 0.5-mm width, each divided into eight sectors. Agreement was analyzed by mean difference (OCT – VHFDU), 95% limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland–Altman analysis. In virgin epithelium, mean central thickness was 53.4 ± 3.20 μm (range: 46 to 62 μm) with OCT and 54.1 ± 2.96 μm (range: 48 to 61 μm) with VHFDU; OCT measured thinnest in 70% with a mean difference of −0.71 μm (95% LoA of ±3.94 μm, P < .001). In post-LRS epithelium, mean central thickness was 57.9 ± 6.08 μm (range: 42 to 77 μm) with OCT and 60.5 ± 6.47 μm (range: 42 to 79 μm) with VHFDU; OCT measured thinnest in 88%, with a mean difference of −2.48 μm (95% LoA of ±5.33 μm, P < .001). A larger difference between methods was more common with thicker epithelium. Corneal epithelial thickness measurements using OCT were found to be slightly thinner than for VHFDU. In contrast to VHFDU, OCT measurement includes the tear film, so the true difference is probably approximately 4 μm more than reported. The difference was greatest inferiorly and higher for post-LRS eyes and in thicker epithelium.