Toxicity of Herbs, Vitamins, and Supplements
Toxicity of Herbs, Vitamins, and Supplements
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DOI：
10.1053/j.ackd.2019.08.003
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Harbord, Nikolas
中科院分区：
文献类型：
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作者：
Charen, Elliot;Harbord, Nikolas
在美国，食品和药物管理局负责监管药物的有效性和安全性。这个政府机构的成立是为了直接应对大规模中毒和100多人死于肾衰竭，原因是药物有毒酒精暴露。相比之下，美国食品和药物管理局（Food and Drug Administration，简称FDA）还对维生素、矿物质、草药或植物性药物作为膳食补充剂的使用进行了监管，禁止特定的医疗声明，但不要求提供疗效证明。膳食补充剂的安全性只能通过报告不良事件来确保，很少通过干预来确保。消费者应该意识到，补充剂实际上可能含有实际的药物或没有任何价值，并具有显着的毒性潜力。综述了中草药、马兜铃酸、苦杏仁甙、维生素D过多症和重金属污染引起的毒性。(C)2019年由国家肾脏基金会，公司。All rights reserved.
In the United States, the Food and Drug Administration regulates the efficacy and safety of pharmaceutical drugs. This government agency was formed in direct response to a mass poisoning and more than 100 deaths from kidney failure due to a medicinal toxic alcohol exposure. In contrast, the Food and Drug Administration also regulates the use of vitamins, minerals, herbs, or botanicals as dietary supplements, banning specific medical claims but requiring no documentation of efficacy. Safety of dietary supplements is only ensured through reporting of adverse events and rarely through intervention. Consumers should be aware that supplements may in fact contain actual pharmaceuticals or nothing of value and have significant toxic potential. Toxicity due to Chinese herbal medicines, aristolochic acid, amygdalin, hypervitaminosis D, and heavy metal contamination is reviewed. (C) 2019 by the National Kidney Foundation, Inc. All rights reserved.