Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice
Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice
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DOI：
10.1210/en.2007-1042
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发表时间：
2008-02-01
期刊：
影响因子：
4.8
通讯作者：
Ashcroft, Gillian S.
中科院分区：
文献类型：
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作者：
Hardman, Matthew J.;Emmerson, Elaine;Ashcroft, Gillian S.
绝经后老年妇女缺乏全身激素导致皮肤伤口愈合延迟。在人类和啮齿动物模型中，这种作用可以通过全身或局部雌激素替代来逆转。近年来，选择性雌激素受体调节剂已被开发，试图在临床上实现雌激素的有益作用，同时使有害的副作用最小化。选择性雌激素受体调节剂对皮肤的影响知之甚少，对伤口愈合的影响尚未评估。在这项研究中，我们用雌二醇、他莫昔芬（TAM）、雷洛昔芬（RAL）或溶剂处理10周龄卵巢切除小鼠，并检查对全层切口伤口愈合的影响。TAM和RAL均显著加速愈合，与抑制的炎症反应和改变的炎症细胞因子谱相关。体外TAM和RAL显示出与雌激素相当的抗肿瘤活性。这些结果对伤口愈合的临床调节具有重要意义。
A lack of systemic hormones in elderly postmenopausal women leads to delayed cutaneous wound healing. This effect can be reversed by systemic or topical estrogen replacement in both humans and rodent models. Over recent years selective estrogen receptor modulators have been developed in an attempt to achieve the beneficial effects of estrogen clinically, while minimizing the detrimental side effects. The effects of selective estrogen receptor modulators on the skin are poorly understood, and the effects on wound healing have not been assessed. In this study we treated 10-wk-old ovariectomized mice with estradiol, tamoxifen (TAM), raloxifene (RAL), or vehicle and examined the effect on healing of full-thickness incisional wounds. Both TAM and RAL substantially accelerate healing, associated with a dampened inflammatory response and altered inflammatory cytokine profile. In vitro TAM and RAL demonstrate antiinflammatory activity comparable to estrogen. These results have significant implications for the clinical modulation of wound healing.