EFFECT OF DIETARY ALPHA-LINOLENIC ACID ON GROWTH, METASTASIS, FATTY-ACID PROFILE AND PROSTAGLANDIN PRODUCTION OF 2 MURINE MAMMARY ADENOCARCINOMAS
EFFECT OF DIETARY ALPHA-LINOLENIC ACID ON GROWTH, METASTASIS, FATTY-ACID PROFILE AND PROSTAGLANDIN PRODUCTION OF 2 MURINE MAMMARY ADENOCARCINOMAS
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DOI：
10.1093/jn/120.12.1601
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发表时间：
1990-12-01
影响因子：
4.2
通讯作者：
JOHNSTON, PV
中科院分区：
文献类型：
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作者：
FRITSCHE, KL;JOHNSTON, PV
本研究的目的是确定膳食（n-3）脂肪酸是否会影响乳腺肿瘤的生长和转移。断奶雌性BALB/c小鼠分别饲喂含有10%玉米油（CO）、亚麻籽油（LO）或鱼油-玉米油混合物（FO）的饲料3-8周，然后皮下注射两种同基因乳腺肿瘤细胞（410和410.4）中的一种。通过监测肿瘤的平均直径和肿瘤切除后的重量来评估肿瘤的生长情况。410.4例乳腺肿瘤中，与对照组相比，豆油组的肿瘤生长降低（p < 0.05），而豆油组的肿瘤生长不降低（p < 0.05）。肿瘤转移数据与肿瘤生长速度一致。饲喂鱼油和鱼油可促进（n-3）脂肪酸在肿瘤中的掺入（p < 0.005）。鱼油和鱼油均能降低肿瘤前列腺素E （PGE）的生成（p < 0.005），鱼油比鱼油更能降低410.4个肿瘤PGE的合成（p < 0.05），但鱼油仅能抑制肿瘤的生长。这些数据表明，膳食亚麻酸[即18:3(n-3)]对乳腺肿瘤的生长和转移有抑制作用。然而，这种影响与饮食引起的PGE合成变化没有直接关系。
The purpose of this study was to determine whether dietary (n-3) fatty acids would affect mammary tumor growth and metastasis. Weanling female BALB/c mice were fed diets that contained 10% corn oil (CO), linseed oil (LO) or a fish oil-corn oil mix (FO) for 3-8 wk prior to receiving subcutaneous injections of one of two syngeneic mammary tumor cell types (410 and 410.4). Tumor growth was assessed by monitoring mean tumor diameter and tumor weight upon removal. Feeding LO, but not FO, reduced the growth (p < 0.05) of 410.4 mammary tumors compared with growth in those fed CO. Metastasis data paralleled the tumor growth rate. Feeding LO and FO enhanced (p < 0.005) incorporation of (n-3) fatty acids into tumors. Tumor prostaglandin E (PGE) production was reduced (p < 0.005) by LO and FO, compared with CO. FO feeding reduced 410.4 tumor PGE synthesis more (p < 0.05) than LO feeding, yet tumor growth was only inhibited by LO. These data suggest an inhibitory effect of dietary linolenic acid [i.e., 18:3(n-3)] on mammary tumor growth and metastasis. However, this effect did not directly correlate with diet-induced changes in PGE synthesis.