The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay.
The eIF4E-binding protein Eap1p functions in Vts1p-mediated transcript decay.
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DOI：
10.1371/journal.pone.0047121
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Smibert CA
中科院分区：
文献类型：
--
作者：
Rendl LM;Bieman MA;Vari HK;Smibert CA
Sequence-specific RNA binding proteins can induce the degradation of mRNAs through their ability to recruit proteins that trigger transcript destabilization. For example, Vts1p, the S. cerevisiae member of the Smaug family of RNA binding proteins, is thought to induce transcript decay by recruiting the Ccr4p-Pop2p-Not deadenylase complex to target mRNAs. The resulting deadenylation triggers transcript decapping followed by 5′-to-3′ exonucleolytic decay. Here we show that the eIF4E-binding protein, Eap1p, is required for efficient degradation of Vts1p target transcripts and that this role involves the ability of Eap1p to interact with eIF4E. Eap1p does not stimulate deadenylation of Vts1p target transcripts but is instead involved in decapping. Eap1p interacts with Vts1p and mediates an indirect interaction between Vts1p and eIF4E. Taken together these data suggest a model whereby the interaction of Vts1p with Eap1p at target mRNAs stimulates decapping.
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DOI：
10.1083/jcb.200504039
发表时间：
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期刊：
The Journal of cell biology
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