Morbidity and accidents in patients with epilepsy: Results of a European cohort study
Morbidity and accidents in patients with epilepsy: Results of a European cohort study
复制标题
DOI：
10.1046/j.1528-1157.2002.18701.x
复制
发表时间：
2002-09-01
期刊：
影响因子：
5.6
通讯作者：
Cornaggia, C
中科院分区：
文献类型：
--
作者：
Beghi, E;Cornaggia, C
目的：评估癫痫患者发生疾病和意外事故的风险，并评估癫痫所致风险的比例。方法：对来自8个欧洲国家（意大利、德国、荷兰、英国、葡萄牙、俄罗斯、爱沙尼亚和斯洛文尼亚）的951例特发性、隐源性或远端症状性癫痫转诊患者和909例匹配对照（亲属或朋友）进行前瞻性随访1-2年。每个病人和对照组都收到一本日记，记录任何疾病或事故。癫痫患者特别记录了与癫痫发作的关系。结果：644名患者记录了2491种疾病，而508名对照者记录了1665种疾病。患者12个月时的累计患病概率为49%，24个月时为86%（对照，39%和75%；p < 0.0001）。199名患者和124名对照组分别发生了270起和140起事故。12个月和24个月时，病例的累计事故概率分别为17%和27%（对照组）。12%和17%；P < 0.0001)。患者患两种或两种以上疾病或事故的几率不大，但明显更高。疾病和事故大多是微不足道的。30%的疾病和24%的事故与癫痫发作有关。当排除与癫痫发作相关的疾病和意外事故时，两组的疾病和意外事故发生的几率相当相似。隐源性或远端症状性癫痫患者患病和发生事故的风险高于一般人群。除了少数例外，这些事件都是微不足道的。排除癫痫相关事件。癫痫患者患病和发生事故的风险并没有明显增加。
Purpose: To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy.Methods: Nine hundred fifty-one referral patients with idiopathic, cryptogenic, or remote symptomatic epilepsy and 909 matched controls (relatives or friends) were followed up prospectively for 1-2 years in eight European countries (Italy, Germany, Holland, England, Portugal, Russia, Estonia, and Slovenia). Each patient and control received a diary to keep notes regarding any illness or accident. Patients with epilepsy specifically recorded relations with seizures.Results: Six hundred forty-four patients recorded 2,491 illnesses compared with 1,665 illnesses in 508 controls. The cumulative probability of illness in patients was 49% by 12 months and 86% by 24 months (controls, 39 and 75%; p < 0.0001). One hundred ninety-nine patients and 124 controls had 270 and 140 accidents, respectively. The Cumulative probability of accident in the cases was 17 and 27% by 12 and 24 months (controls. 12 and 17%; p < 0.0001). The chance of two or more illnesses or accidents was modestly but significantly greater in the patients. Illnesses and accidents were mostly trivial. Thirty percent of illnesses and 24% of accidents were seizure related. When illnesses and accidents related to seizures were excluded, the chance of illnesses and accidents was fairly similar in the two groups,Conclusions: Patients with idiopathic. cryptogenic, or remote symptomatic epilepsy have a moderately higher risk of illnesses and accidents than do the general Population. With few exceptions, the events are trivial. When seizure-related events are excluded. patients with epilepsy are not at any significantly higher risk of illnesses and accidents.