Different concentrations of various radiopharmaceuticals in the two main liver lobes:: a preliminary study in clinical patients
Different concentrations of various radiopharmaceuticals in the two main liver lobes:: a preliminary study in clinical patients
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DOI：
10.1007/s00535-005-1617-9
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发表时间：
2005-07-01
影响因子：
6.3
通讯作者：
Larsson, SA
中科院分区：
文献类型：
--
作者：
Jacobsson, H;Jonas, E;Larsson, SA
背景在使用单光子发射计算机断层扫描（SPECT）进行的腹部临床造影检查中，我们观察到各种放射性药物在左和右主肝叶之间的不同分布。这是回顾性研究在临床患者。用[I-123]-间碘苄胍MIBG（n = 19）、Tc-99标记的抗粒细胞单克隆抗体（n = 18）和In-111-喷替曲肽（n = 26）进行检查。没有已知的肝病史或风险因素，所有肺叶显示出均匀的活动分布。20名健康志愿者连续接受了Tc-99-二甲基亚氨基二乙酸（希达）检查。计算肝左、右主肝叶的活动比值。[I-123]-MIBG的左：右叶活性比为（平均值+/-SD）1.25 +/-0.21（零假设= 1.00; P <0.001）;对于抗体，3 - 5小时后的采集值为0.98 +/-0.06（NS），20 - 24小时后为0.99 +/-0.11（NS）;对于In-111-喷替曲肽，为0.90 +/-0.09（P <0.001）;对于Tc-99-希达，立即采集，0.68 +/-0.12（P <0.001），7分钟采集，0.66 +/-0.12（P <0.001）。结论。肝叶之间示踪剂摄取的差异不能仅由血流的差异引起。左叶对[I-123]-MIBG摄取较高的一种解释可能是该肝脏部分存在较多的儿茶酚胺和较高的交感神经密度。因此，两个主要肝叶之间可能存在功能差异。
Background. At clinical scintigraphic examinations of the abdomen using single photon emission computed tomography (SPECT), we have observed a different distribution between the left and right main liver lobes of various radiopharmaceuticals. This was studied retrospectively in clinical patients.Methods. Examinations with [I-123]-metaiodobenzylguanidine MIBG; (n = 19), a Tc-99-labelled monoclonal antibody against granulocytes (n = 18), and In-111-pentetreotide (n = 26) were assessed. There was no known history of, or risk factor for liver disease, and all lobes showed a uniform activity distribution. Twenty healthy volunteers underwent consecutive examinations with Tc-99-dimethyliminodiacetic acid (HIDA). The activity ratios between the left and right main liver lobes were calculated from the transverse tomographic (SPECT) sections.Results. The left:right lobar activity ratio for [I-123]-MIBG was (mean +/- SD) 1.25 +/- 0.21 (null hypothesis = 1.00; P < 0.001); for the antibody, acquisition after 3-5h was 0.98 +/- 0.06 (NS) and after 20-24h, 0.99 +/- 0.11 (NS); for In-111-pentetreotide, 0.90 +/- 0.09 (P < 0.001); for Tc-99-HIDA, immediate acquisition, 0.68 +/- 0.12 (P < 0.001) and acquisition at 7min, 0.66 +/- 0.12 (P < 0.001).Conclusions. The differences in tracer uptake between the liver lobes cannot be caused only by differences in blood flow. One explanation of the higher uptake of [I-123]-MIBG by the left lobe may be a greater presence of catecholamines and a higher sympathetic nerve density in this liver portion. Consequently, there may be a functional difference between the two main liver lobes.