Delivery and Efficacy of a Cancer Drug as a Function of the Bond to the Gold Nanoparticle Surface
Delivery and Efficacy of a Cancer Drug as a Function of the Bond to the Gold Nanoparticle Surface
复制标题
DOI：
10.1021/la902390d
复制
发表时间：
2010-02-16
期刊：
影响因子：
3.9
通讯作者：
Burda, Clemens
中科院分区：
文献类型：
--
作者：
Cheng, Yu;Samia, Anna C.;Burda, Clemens
在这篇专题文章中，我们制备了载药于酞菁的纳米金结合物，并测试了其对HeLa癌细胞的输送效率和光动力治疗效果。结果表明，药物载量与纳米颗粒表面之间的键对药物传递和光动力疗法的结果有很大的影响。不稳定的氨基吸附到AN纳米颗粒表面可以使药物有效地释放到癌细胞中，从而实现高效的光动力治疗，而AN纳米颗粒上的共价硫醇键导致药物进入细胞囊泡，没有观察到PDT效应。这项工作强调了仔细选择药物分子和纳米颗粒表面之间相互作用的重要性。
In this feature article, gold nanoparticle Conjugates loaded with phthalocyanine-based PDT drugs are prepared and tested for delivery efficiency and PDT efficacy oil HeLa cancer cells. It could be shown that the delivery and PDT outcome are strongly affected by the bond that links the drug load to the nanoparticle Surface. Whereas labile amino adsorption to the An nanoparticle surface allows for efficient drug release into the cancer cells and for efficient PDT, a covalent thiol bond to the An nanoparticle leads to the delivery of the drug into cell vesicles, and no PDT effect is observed. This work highlights the importance of carefully choosing the interaction between drug molecules and the nanoparticle surface.