Low levels of ventricular CSF orexin/hypocretin in advanced PD
Low levels of ventricular CSF orexin/hypocretin in advanced PD
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DOI：
10.1212/01.wnl.0000078194.53210.48
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发表时间：
2003-08-26
期刊：
影响因子：
9.9
通讯作者：
d'Ortho, MP
中科院分区：
文献类型：
--
作者：
Drouot, X;Moutereau, S;d'Ortho, MP
帕金森病(PD)患者白天过度嗜睡的原因尚不清楚。作者假设，食欲素神经元，一种最近发现的觉醒促进系统，可能对其病理生理学有贡献。他们检测了19名帕金森病患者脑室脑脊液中食欲素-A/降钙素-1的浓度，并将其与神经科对照组进行了比较。食欲素水平在患者中较低，且随着疾病的严重程度而降低。作者认为食欲素神经元参与了晚期帕金森病患者的日间嗜睡。
The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.