CD109 expression is upregulated in penile squamous cell carcinoma.
CD109 expression is upregulated in penile squamous cell carcinoma.
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CD109在阴茎鳞状细胞癌中表达上调
DOI：
10.3892/ol.2017.6975
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发表时间：
2017-11
期刊：
影响因子：
2.9
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Dong F;Wang J;Xu Y;Cheng Z;Chen X;Wang Y;Liu J
分化簇 (CD) 109 是一种糖基磷脂酰肌醇锚定的细胞表面糖蛋白，也是转化生长因子 β 的共受体。 CD109的表达已在肺、食道、皮肤和胆囊的鳞状细胞癌中检测到。本研究的目的是评估阴茎鳞状细胞癌（PSCC）中 CD109 的表达。通过免疫组织化学分析检查组织微阵列中 45 个样本的 PSCC 肿瘤和邻近组织中的 CD109 表达。此外，收集了 3 份新鲜的 PSCC 手术样本，并通过逆转录定量聚合酶链反应、蛋白质印迹和免疫荧光染色检查了其 CD109 mRNA 和蛋白质水平。 CD109在PSCC组织中的转录和表达量显着高于邻近的正常阴茎组织，且其表达仅限于鳞状细胞。然而，CD109表达水平与PSCC分化程度无关。这些结果表明CD109可能与PSCC的发病机制有关，因此可能是潜在的治疗靶点。
Cluster of differentiation (CD) 109 is a glycosylphosphatidylinositol‑anchored cell surface glycoprotein and a co‑receptor for transforming growth factor β. The expression of CD109 has been detected in squamous cell carcinoma of the lung, esophagus, skin and gallbladder. The aim of the present study was to evaluate CD109 expression in penile squamous cell carcinoma (PSCC). CD109 expression in PSCC tumor and adjacent tissues from 45 specimens in tissue microarrays was examined by immunohistochemical analyses. In addition, 3 fresh surgical samples of PSCC were collected and examined for their CD109 mRNA and protein levels by reverse transcription‑quantitative polymerase chain reaction, western blotting and immunofluorescence staining. CD109 transcription and expression were significantly higher in the PSCC tissues compared with adjacent normal penile tissues, and its expression was restricted to squamous cells. However, CD109 expression level was not associated with the PSCC differentiation grade. These results suggest that CD109 may be associated with the pathogenesis of PSCC, and may therefore be a potential therapeutic target.
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影响因子：
3.8
作者：
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通讯作者：
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作者：
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