Animal models of intestinal inflammation: ineffective communication between coalition members
Animal models of intestinal inflammation: ineffective communication between coalition members
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DOI：
10.1007/s00281-005-0208-4
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发表时间：
2005-06-01
期刊：
影响因子：
--
通讯作者：
Elson, CO
中科院分区：
文献类型：
--
作者：
Lorenz, RG;McCracken, VJ;Elson, CO
肠道中的微生物群、上皮细胞和粘膜免疫细胞构成了重要的胃肠道联盟。肠道微生物群可以对其动物宿主产生有益和有害的影响。它们通过微生物识别受体与上皮细胞提供的先天防御相互作用。在正常情况下，这种沟通会导致炎症受控。本文将重点介绍几种肠道炎症的动物模型，其中自发或诱导突变或其他遗传操作导致胃肠道联盟成员之一发生严重改变。这些结肠炎的动物模型表明，该联盟成员之间的交流改变最终导致胃肠道疾病。
The microbiota, epithelial cells, and mucosal immune cells in the intestine comprise an important gastrointestinal coalition. The intestinal microbiota can exert both beneficial as well as deleterious effects on their animal hosts. They interact with the innate defenses provided by epithelial cells through microbial recognition receptors. This communication, under normal conditions, results in a state of controlled inflammation. This article will focus on several animal models of intestinal inflammation, in which spontaneous or induced mutations or other genetic manipulations result in severe alterations in one of the members of the gastrointestinal coalition. These animal models of colitis have shown that alterations in communication between members of this coalition ultimately lead to gastrointestinal disease.