Biobanking for necrotizing enterocolitis: Needs and standards
Biobanking for necrotizing enterocolitis: Needs and standards
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DOI：
10.1016/j.jpedsurg.2019.05.002
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发表时间：
2020-07-01
影响因子：
2.4
通讯作者：
Good, Misty
中科院分区：
文献类型：
--
作者：
Chaaban, Hala;Markel, Troy A.;Good, Misty
背景：坏死性小肠结肠炎（NEC）是一种严重的胃肠道疾病，主要影响早产儿。尽管医学进步，NEC的死亡率和发病率仍然高得令人无法接受。这部分是因为缺乏针对这种疾病的特定生物标志物和治疗方法。早产儿高质量生物学样本和相关LIMA的可用性是促进我们对NEC的理解以及生物标志物发现和药物开发的关键。为此，NEC协会生物库的建立，通过共享专门的生物标本和NEC research.Objective数据采购促进人类婴儿的研究的目标：在这篇综述中，我们将讨论所需的基础设施的生物库，讨论信息管理的重要性，并强调共享标本的后勤要求。最后，我们将讨论如何组织和材料将共享institutions.Conclusion：我们已经开发了一个国家的最先进的人类婴儿的生物银行，以推进NEC研究的举行的机制。通过NEC Society Biorepositofy，我们寻求促进和加速NEC的基础和转化研究，为患有NEC的婴儿及其家人提供希望。研究类型：综述文章，V级（C）2019 Elsevier Inc. All rights reserved.
Background: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premaLure infants. Despite medical advances, mortality and morbidity from NEC are still unacceptably high. This is partly because of the lack of specific biomarkers and therapies for this disease. Availability of high qualitybiological samples and the associated LIMA from premature infants are key to advance our understanding of NEC, and for biomarker discovery and drug development. To that end, the NEC Society Biorepository was established with the goal of promoting studies in human infants through sharing specialized biospecimen and data procurement for NEC research.Objective: In this review, we will discuss the required infrastructure for biobanks, discuss the importance of informatics management, and emphasize the logistical requirements for sharing specimens. Finally, we will discuss the mechanism for how tissues and material will be shared between the institutions.Conclusion: We have developed a state-of-the-art biobank for human infants to advance the held of NEC research. With the NEC Society Biorepositofy, we seek to facilitate and accelerate the basic and translational studies on NEC to provide hope to the infants afflicted with NEC and their families. Study type: Review article, level V. (C) 2019 Elsevier Inc. All rights reserved.