Suppressed Sensory Response to Predictable Object Stimuli throughout the Ventral Visual Stream
Suppressed Sensory Response to Predictable Object Stimuli throughout the Ventral Visual Stream
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DOI：
10.1523/jneurosci.3421-17.2018
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发表时间：
2018-08-22
影响因子：
5.3
通讯作者：
de lange, Floris P.
中科院分区：
文献类型：
--
作者：
Richter, David;Ekman, Matthias;de lange, Floris P.
正如预测编码理论所强调的那样，预测在感知中起着至关重要的作用。然而，感觉处理的预测调节的确切形式和机制仍不清楚，一些研究报告了对可预测输入的感觉反应下调，而其他研究则观察到反应增强。同样，对可预测输入的感觉反应的下调与感觉表征的锐化或减弱有关，这在本质上是相反的。在本研究中，我们着手在人类志愿者中使用功能磁共振成像来研究整个视觉层次中物体刺激的感知预期的神经后果。男女参与者都在统计学习范式中接触到成对的顺序呈现的物体图像，其中第一个物体预测第二个物体的身份。图像转换与任务无关；因此，所有统计规律的学习都是偶然的。我们发现，与预期刺激相比，整个腹侧视觉流（包括初级视觉皮层、外侧枕叶复合体和前腹侧视觉区域）的神经反应受到强烈抑制。枕叶外侧复合体的期望抑制与图像偏好和体素选择性成正比，这为物体感知中期望抑制的抑制解释提供了支持。
Prediction plays a crucial role in perception, as prominently suggested by predictive coding theories. However, the exact form and mechanism of predictive modulations of sensory processing remain unclear, with some studies reporting a downregulation of the sensory response for predictable input whereas others observed an enhanced response. In a similar vein, downregulation of the sensory response for predictable input has been linked to either sharpening or dampening of the sensory representation, which are opposite in nature. In the present study, we set out to investigate the neural consequences of perceptual expectation of object stimuli throughout the visual hierarchy, using fMRI in human volunteers. Participants of both sexes were exposed to pairs of sequentially presented object images in a statistical learning paradigm, in which the first object predicted the identity of the second object. Image transitions were not task relevant; thus, all learning of statistical regularities was incidental. We found strong suppression of neural responses to expected compared with unexpected stimuli throughout the ventral visual stream, including primary visual cortex, lateral occipital complex, and anterior ventral visual areas. Expectation suppression in lateral occipital complex scaled positively with image preference and voxel selectivity, lending support to the dampening account of expectation suppression in object perception.