Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial.
Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial.
复制标题
DOI：
--
复制
发表时间：
1996
影响因子：
5
通讯作者：
S. Haffner;J. Shaten;M. P. Stern;G. D. Smith;L. Kuller
中科院分区：
文献类型：
--
作者：
S. Haffner;J. Shaten;M. P. Stern;G. D. Smith;L. Kuller
关于性激素结合球蛋白（SHBG）、睾酮与糖尿病发病风险之间的关系，目前几乎没有前瞻性数据。从1973年12月到1976年2月，在美国22个中心参加多危险因素干预试验（MRFIT）的参与者的储存空腹血清样本用于进行巢式病例对照研究。对于176名在5年随访期间发生糖尿病的初始非糖尿病男性，选择两个对照，一个仅匹配随机化日期，治疗组和诊所（“松散对照”），另一个匹配空腹血糖和体重指数（“严格对照”）。当病例与失去控制相比时，较高水平的空腹胰岛素和较低水平的总睾酮和游离睾酮以及SHBG与糖尿病的发展显著相关。然而，当将病例与严格匹配的对照组进行比较时，这些关联大大减弱。低SHBG和睾酮可能构成男性糖尿病前期状态的一部分，沿着先前报道的变量，如较高的葡萄糖和胰岛素水平以及肥胖。
Few prospective data are available regarding the association of sex hormone-binding globulin (SHBG), testosterone, and the risk of developing diabetes. Stored fasting serum samples from participants enrolled in the Multiple Risk Factor Intervention Trial (MRFIT) at 22 centers throughout the United States from December 1973 through February 1976 were used to perform a nested case- control study. For 176 initially nondiabetic men who had developed diabetes during 5 years of follow-up, two controls were selected, one matched only for randomization date, treatment group, and clinic ("loose controls") and the other matched additionally for fasting glucose and body mass index ("tight controls"). When cases were compared with lose controls, higher levels of fasting insulin and lower levels of total and free testosterone and SHBG were significantly associated with increased development of diabetes. However, when cases were compared with tightly matched controls, these associations weakened considerably. Low SHBG and testosterone may constitute part of the prediabetic state in men along with previously reported variables, such as higher glucose and insulin levels and obesity.