HOT PLATE VERSUS TAIL-FLICK - EVALUATION OF ACUTE TOLERANCE TO CONTINUOUS MORPHINE INFUSION IN THE RAT MODEL
HOT PLATE VERSUS TAIL-FLICK - EVALUATION OF ACUTE TOLERANCE TO CONTINUOUS MORPHINE INFUSION IN THE RAT MODEL
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DOI：
10.1016/1056-8719(94)00077-h
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发表时间：
1995-09-01
影响因子：
1.9
通讯作者：
GRANT, GJ
中科院分区：
文献类型：
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作者：
LANGERMAN, L;ZAKOWSKI, MI;GRANT, GJ
采用两种不同的伤害感觉评价方法：甩尾法（tail flick， TF）和热板法（hot plate， HP）评价大鼠对吗啡连续输注(2、4和6 mg x kg（-1) x hr(-1)）的耐受性发展。使用两种方案评估重复测试对伤害感觉的影响；系列1在吗啡输注后1、2、4、6和8小时反复检测，系列2仅在吗啡作用最大时和8小时检测两次。吗啡给药4或6 mg x kg(-1) x hr（-1）后，TF和HP均出现痛阈升高，并在开始注射后2小时达到最大值。HP：在重复测试的系列中，发现4mg x kg(-1) x hr（-1）组的效果降低；6 mg x kg(-1) x hr（-1）组两组的效果均有所降低。TF: 8小时时反应潜伏期没有减少。由于TF主要是脊柱反应，HP主要是脊柱上反应，结果表明吗啡输注前8小时的耐受性主要在脊柱上水平产生。
The development of tolerance to continuous morphine infusion (2,4 and, 6 mg x kg(-1) x hr(-1)) was assessed in rats using two different methods for evaluation of nociception, tail flick (TF) and hot plate (HP). The influence of repeated testing on nociception was evaluated using two regimens; series 1 was tested repeatedly 1, 2, 4, 6, and 8 hr after initiating the morphine infusion and series 2 was tested only twice, at maximum morphine effect and at 8 hr. Both, TF and HP showed pain threshold elevation after the morphine administration of 4 or 6 mg x kg(-1) x hr(-1), which reached a maximum at 2 hr after the start of the infusion. HP: reduction of the effect was found in group 4 mg x kg(-1) x hr(-1) in the series subjected to repeated testing; group 6 mg x kg(-1) x hr(-1) showed reduced effect in both series. TF: the response latencies did not show reduction at 8 hr. Since TF is predominantly a spinal response and HP is predominantly supraspinal, the results suggest that tolerance during the first 8 hr of morphine infusion develops mainly at supraspinal level.