N-Phenoxyamides as Multitasking Reagents: Base-Controlled Selective Construction of Benzofurans or Dihydrobenzofuro[2,3-d]oxazoles
N-Phenoxyamides as Multitasking Reagents: Base-Controlled Selective Construction of Benzofurans or Dihydrobenzofuro[2,3-d]oxazoles
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N-苯氧酰胺作为多任务试剂：苯并呋喃或二氢苯并呋喃并[2,3-d]恶唑的碱控选择性构建
DOI：
10.1021/acs.joc.9b00858
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发表时间：
2019
影响因子：
3.6
通讯作者：
Wen Li Rong
中科院分区：
文献类型：
--
作者：
Li Ming;Wang Jia Hui;Li Wei;Lin Cheng Dong;Zhang Lin Bao;Wen Li Rong
通过N-苯氧基酰胺与1-[（三异丙基硅基）乙炔基]-1，2-苯碘酰-3（1H）-酮（TIPS-EBX）的碱控环化反应，建立了一种选择性合成苯并呋喃和二氢苯并呋喃并[2，3-d]恶唑衍生物的方法。这是在无金属条件下使用TIPS-EBX将C（sp）转化为C（sp2）或C（sp3）的第一个例子。
An efficient method to selectively construct benzofuran and dihydrobenzofuro[2,3-d]oxazole derivatives has been successfully established by means of base-controlled cyclization ofN-phenoxyamides with 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX).N-phenoxyamides as multitasking reagents have triggered two different cascade reaction sequences. This is the first example of using TIPS-EBX for the transformation of C(sp) to either C(sp2) or C(sp3) under metal-free conditions.