Ontology for immunogenetics: the IMGT-ONTOLOGY
Ontology for immunogenetics: the IMGT-ONTOLOGY
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DOI：
10.1093/bioinformatics/15.12.1047
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发表时间：
1999-12-01
期刊：
影响因子：
5.8
通讯作者：
Lefranc, MP
中科院分区：
文献类型：
--
作者：
Giudicelli, V;Lefranc, MP
动机：IMGT，国际ImMunoGeneTics数据库（http：//imgt.cines.fr：8104），由M.- P. Lefranc是一个专门研究所有脊椎动物物种的抗原受体（免疫球蛋白和T细胞受体）和主要组织相容性复合体（MHC）的综合数据库。IMGT准确的免疫遗传学数据是基于“ImmMunoGeneTics”IMGT-ontology提供的生物学知识的标准化。IMGT-ontology描述了免疫遗传学和生物信息学所需术语的分类和规范。IMGT本体论涵盖了四个主要概念：“识别”，“分类”和“获取”。这些概念允许对免疫球蛋白和T细胞受体数据进行广泛和标准化的描述和表征。控制词汇和注释规则是保证IMGT的准确性、一致性和连贯性不可或缺的。IMGT-ontology允许科学家和临床医生首次使用免疫遗传学中具有相同含义的相同术语。它提供了一个语义存储库，将提高专家和通才数据库之间的互操作性。
Motivation: IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104), created by M.-P. Lefranc, is an integrated database specializing in antigen receptors (immunoglobulins and T-cell receptors) and major histocompatibility complex (MHC) of all vertebrate species. IMGT accurate immunogenetics data ave based on the standardization of the biological knowledge provided by the 'ImMunoGeneTics' IMGT-ONTOLOGY.The IMGT-ONTOLOGY describes the classification and specification of terms needed for immunogenetics and bioinformatics. IMGT-ONTOLOGY covers four main concepts: 'IDENTIFICATION', 'DESCRIPTION', 'CLASSIFICATION' and 'OBTENTION'. These concepts allow an extensive and standardized description and characterization of immunoglobulin and T-cell receptor data. The controlled vocabulary and the annotation rules ave indispensable to ensure accuracy, consistency and coherence in IMGT. IMGT-ONTOLOGY allows scientists and clinicians to use, for the first time, identical terms with the same meaning in immunogenetics. It provides a semantic repository that will improve interoperability between specialist and generalist databases.