Occurrences and distribution of sulfonamide and tetracycline resistance genes in the Yangtze River Estuary and nearby coastal area
Occurrences and distribution of sulfonamide and tetracycline resistance genes in the Yangtze River Estuary and nearby coastal area
复制标题
长江口及邻近沿海地区磺胺类和四环素类耐药基因的出现与分布
DOI：
10.1016/j.marpolbul.2015.08.036
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发表时间：
2015-11-15
影响因子：
5.8
通讯作者：
Chen, Baowei
中科院分区：
文献类型：
--
作者：
Lin, Lan;Yuan, Ke;Chen, Baowei
高度受影响的河口的作用，需要检查抗生素耐药基因在环境中的传播。磺胺类药物抗性基因（sul）、四环素类药物抗性基因（泰特）和I类整合子基因（inn）在长江口及其附近海域沉积物中普遍存在，且从河口内向沿岸呈下降趋势。只有int 1基因和sul1基因之间存在良好的相关性，提示int 1基因对sul1基因的增殖是必需的。int1基因与16SrRNA基因之间的相关性不显著，表明int1基因来源于ARG污染源，而不是环境细菌群体固有的。磺胺类化合物在该地区沉积物中的检出率很低，不可能导致当地环境中产生sul基因。(C)2015爱思唯尔有限公司版权所有。
The role of highly impacted estuaries needs to be examined with respect to the spread of antibiotic resistance genes in the environment. In the present study, sulfonamide resistance (sul), tetracycline resistance (tet) and class I integron (inn) genes were ubiquitous in the sediments of the Yangtze Estuary (YE) and nearby coastal area, and exhibited a declining trend from the inner estuary to the coast. Good relationships were only observed between int1 and sul1 genes, implying that int1 gene is essential to the proliferation of sul1 gene. A non-significant correlation between int1 and 16S rRNA genes indicated that the int1 gene came from pollution sources of ARGs instead of being intrinsic in environmental bacterial populations. Sulfonamides were rarely detected in the sediments of this region, so could not result in the production of sul genes in the local environment. (C) 2015 Elsevier Ltd. All rights reserved.