CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis
CC chemokine ligand 2 and CXC chemokine ligand 8 as neutrophil chemoattractant factors in canine idiopathic polyarthritis
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DOI：
10.1016/j.vetimm.2016.09.009
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发表时间：
2016-12-01
影响因子：
1.8
通讯作者：
Matsuki, Naoaki
中科院分区：
文献类型：
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作者：
Murakami, Kohei;Maeda, Shingo;Matsuki, Naoaki
犬特发性多关节炎（IPA）的特征是滑液（SF）中多形核白细胞（PMN）数量增加。在人类中，CC趋化因子配体2（CCL 2）和CXC趋化因子配体8（CXCL 8）分别募集单核细胞和嗜中性粒细胞，并参与各种炎性疾病。本研究的目的是评估这些趋化因子在驱动中性粒细胞浸润到IPA犬关节中的作用。从IPA犬（n = 19）和健康对照犬（n = 8）采集SF样品，并通过ELISA测定SF CCL 2和CXCL 8的浓度。与健康对照组（235 +/- 45 pg/ml，平均值+/- SD）相比，患有IPA的狗具有显著更高浓度的CCL 2（3316 +/- 2452 pg/ml，平均值+/- SD）和CXCL 8（3668 +/- 3879 pg/ml）。
Canine idiopathic polyarthritis (IPA) is characterized by increased numbers of polymorphonuclear leukocytes (PMNs) in the synovial fluid (SF). In humans, CC chemokine ligand 2 (CCL2) and CXC chemokine ligand 8 (CXCL8) recruit monocytes and neutrophils, respectively, and are involved in various inflammatory disorders. The aim of this study was to assess the roles of these chemokines in driving PMNs infiltration into the joints of dogs with IPA. SF samples were collected from dogs with IPA (n = 19) and healthy controls (n = 8), and the concentrations of SF CCL2 and CXCL8 were determined by ELISA. Dogs with IPA had significantly higher concentrations of CCL2 (3316 +/- 2452 pg/ml, mean +/- SD) and CXCL8 (3668 +/- 3879 pg/ml) compared with the healthy controls (235 +/- 45 pg/ml and