Stress echocardiography: diastole to the rescue.
Stress echocardiography: diastole to the rescue.
复制标题
负荷超声心动图：舒张期来救援。
DOI：
10.1016/j.jacc.2008.11.015
复制
发表时间：
2009
影响因子：
24
通讯作者：
Liang,Hsin-Yueh
中科院分区：
文献类型：
--
作者：
Abraham,TheodoreP;Liang,Hsin-Yueh
Assessment of myocardial ischemia by echocardiography rests on the detection of systolic wall motion abnormalities, namely, reduced wall thickening. Traditionally, this assessment is performed visually and is therefore subjective and variable (1). Tissue Doppler and strain echocardiography that allow quantitation of regional myocardial mechanics recently have been shown to be accurate in detection of coronary artery disease (CAD)(2–4). Although there has been a focus on assessment of systolic abnormalities, ischemia also affects diastole. Several processes mediating relaxation at the subcellular level are energy dependent. Myocardial contraction is prompted by cytosolic calcium binding troponin C, resulting in disinhibition of troponin I and actin–myosin cross-bridge formation. Two important mechanisms in reversing these interactions resulting in
