Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles
Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles
复制标题
肿瘤细胞来源的细胞外囊泡的治疗用途
DOI：
10.1007/978-1-4939-7253-1_35
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Huang, Bo
中科院分区：
文献类型：
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作者：
Liu, Jing;Ma, Jingwei;Huang, Bo
细胞外囊泡是一种纳米尺度的膜囊泡，可由多种细胞释放，是抗肿瘤治疗的理想给药系统。外周小体、微粒(MP)和凋亡小体是EVS的三种主要类型。MPS是尺寸在100到1000纳米之间的电动汽车。肿瘤细胞来源的EVS(T-EVS)可以作为一种安全有效的载体来特异性地输送化疗药物或溶瘤腺病毒用于肿瘤治疗。在这一节中，我们将介绍如何准备电动汽车用于治疗。
Extracellular vesicles (EVs) are nanosized membrane vesicles, released by many cell types, which are an ideal drug-delivery system for antitumor therapy. Exosomes, microparticles (MP), and apoptotic bodies are the three main types of EVs. MPs are EVs with size ranges between 100 and 1000 nm. Tumor cell-derived EVs (T-EVs) can serve as a safe and efficient vehicle to specific deliver chemotherapeutic drugs or oncolytic adenoviruses for tumor treatment. In this section, we describe how to prepare EVs for therapeutic use.