Specification of the germ cell lineage in mice.
Specification of the germ cell lineage in mice.
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DOI：
10.2741/3294
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Saitou
中科院分区：
文献类型：
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作者：
M. Saitou
生殖细胞谱系的特化是发育和遗传的基础。在小鼠中，大概在所有哺乳动物中，生殖细胞的命运不是从卵细胞遗传的特征，而是由信号分子在多能外胚层细胞中诱导的。最近的研究开始揭示小鼠生殖细胞谱系特化的信号传导要求和关键转录调节因子，以及特定生殖细胞独特获得的独特特性。因此，证据表明，生殖细胞特化是体细胞程序的抑制、潜在多能性的重新获得和随后的全基因组表观遗传重编程的整合。积累的知识将是至关重要的重建这一关键谱系在体外，这可能会提供一个有用的基础，生殖和再生医学。
Specification of the germ cell lineage is fundamental in development and heredity. In mice, and presumably in all mammals, germ cell fate is not an inherited trait from the egg, but is induced in pluripotent epiblast cells by signaling molecules. Recent studies are beginning to uncover the signaling requirements and key transcriptional regulators for the specification of the germ cell lineage in mice, as well as the distinct properties that the specified germ cells acquire uniquely. Accordingly, the evidence suggests that germ cell specification is an integration of the repression of the somatic program, re-acquisition of potential pluripotency, and ensuing genome-wide epigenetic reprogramming. The accumulated knowledge will be critical for the reconstitution of this key lineage in vitro, which may provide a useful foundation for reproductive and regenerative medicine.