Asymmetric substitution patterns: a review of possible underlying mutational or selective mechanisms
Asymmetric substitution patterns: a review of possible underlying mutational or selective mechanisms
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DOI：
10.1016/s0378-1119(99)00297-8
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发表时间：
1999-09-30
期刊：
影响因子：
3.5
通讯作者：
Lobry, JR
中科院分区：
文献类型：
--
作者：
Frank, AC;Lobry, JR
在两条DNA链之间不存在突变和选择的偏倚的情况下，每条链内的碱基组成应该是A=T和C=G（这种状态称为奇偶规则2型，PR2）。在基因组尺度上，即当考虑整个基因组的碱基组成时，PR 2是一个很好的近似值，但存在局部和系统偏差。问题是这些偏差是否是突变或选择中潜在偏见的结果。我们试图回顾已发表的假说，将其归类为突变组或选择组。然而，这种二分法过于粗糙，因为至少有一种假说同时基于突变和选择。(C)1999 Elsevier Science B.V.保留所有权利。
In the absence of bias between the two DNA strands for mutation and selection, the base composition within each strand should be such that A=T and C=G (this state is called Parity Rule type 2, PR2). At a genome scale, i.e. when considering the base composition of a whole genome, PR2 is a good approximation, but there are local and systematic deviations. The question is whether these deviations are a consequence of an underlying bias in mutation or selection. We have tried to review published hypotheses to classify them within the mutational or selective group. This dichotomy is, however, too crude because there is at least one hypothesis based simultaneously upon mutation and selection. (C) 1999 Elsevier Science B.V. All rights reserved.