Nicotine produces selective degeneration in the medial habenula and fasciculus retroflexus
Nicotine produces selective degeneration in the medial habenula and fasciculus retroflexus
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DOI：
10.1016/s0006-8993(01)02570-7
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发表时间：
2001-07-06
期刊：
影响因子：
2.9
通讯作者：
Ellison, G
中科院分区：
文献类型：
--
作者：
Carlson, J;Noguchi, K;Ellison, G
通过渗透微泵以5.01、5.72、6.44、7.13、20.41和43.1毫克/千克/天的剂量连续5天给予酒石酸（-）-尼古丁，或者通过每日一次皮下注射以11.32毫克/千克/天的剂量间歇性给予，对尼古丁在大鼠中的神经毒性特性进行了研究。通过银染评估，除最低剂量组外，在所有治疗组中，神经毒性几乎仅见于内侧缰核的轴突及其传出束——缰核脚间束。在缰核内，损伤见于核的腹内侧部分，该部分被认为富含α4β2和/或α3β4受体亚型。以往的研究表明内侧缰核对尼古丁的作用高度敏感，这些发现结合使用多巴胺能兴奋剂的相关研究表明，缰核可能是滥用兴奋剂药物后所见神经毒性的一个薄弱环节。（C）2001爱思唯尔科学出版社。保留所有权利。
Nicotine's neurotoxic properties in rats were investigated by administering (-)-nicotine tartrate for 5 days either continuously in doses of 5.01. 5.72, 6.44, 7.13, 20.41 and 43.1 mg/kg/day via osmotic minipump or intermittently at 11.32 mg/kg/day via one daily subcutaneous injection. As assessed by silver staining, neurotoxicity was seen almost exclusively in the axons of the medial habenula and its output tract, the fasciculus retroflexus, in all treatment groups except the lowest dose. Within the habenula, the damage was noted in the ventral-medial-most portion of the nucleus which is thought to be dense with the alpha4 beta2 and/or alpha3 beta4 receptor subtypes. Past research has shown the medial habenula to be highly sensitive to the effects of nicotine, and these findings, in conjunction with related research using dopaminergic stimulants, indicate that the habenula may be a weak link in the neurotoxicity seen following stimulant drugs of abuse. (C) 2001 Elsevier Science B.V. All rights reserved.