Evidence for widespread infection of wild rats with hepatitis E virus in the United States
Evidence for widespread infection of wild rats with hepatitis E virus in the United States
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DOI：
10.4269/ajtmh.1999.61.331
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发表时间：
1999-08-01
影响因子：
3.3
通讯作者：
Purcell, RH
中科院分区：
文献类型：
--
作者：
Kabrane-Lazizi, Y;Fine, JB;Purcell, RH
戊型肝炎在许多发展中国家是一种重要的医学病原体，但在美国很少报告，尽管在> 1%的美国公民中发现了戊型肝炎病毒抗体（抗HEV）。怀疑该病毒是动物传染的。从239只被困在美国相隔甚远的地区的野鼠中获得的血清进行了抗HEV测试。来自马里兰州的77%的大鼠、来自夏威夷的90%的大鼠和来自路易斯安那州的44%的大鼠抗HEV血清阳性。来自城市和农村地区的大鼠血清学阳性，抗-HEV IgE的流行率与大鼠的估计年龄平行增加，导致人们猜测它们可能与一些美国城市居民中令人困惑的抗-HEV高流行率有关。在美国大鼠中发现抗-HEV和最近报道的发现HEV在美国猪中流行提出了许多关于发达国家HEV传播、储存库和毒株的问题。
Hepatitis E is an important medical pathogen in many developing countries but is rarely reported from the United States, although antibody to hepatitis E virus (anti-HEV) is found in > 1% of U.S. citizens. Zoonotic spread of the virus is suspected. Sera obtained from 239 wild rats trapped in widely separated regions of the United States were tested for anti-HEV. Seventy-seven percent of rats from Maryland, 90% from Hawaii, and 44% from Louisiana were seropositive for anti-HEV. Rats from urban as well as rural areas were seropositive and the prevalence of anti-HEV Ige increased in parallel with the estimated age of the rats, leading to speculation that they might be involved in the puzzling high prevalence of anti-HEV among some U.S. city dwellers. The discovery of anti-HEV in rats in the United States and the recently reported discovery that HEV is endemic in U.S. swine raise many questions about transmission, reservoirs, and strains of HEV in developed countries.