Developmental Trajectories of Adaptive Behaviors from Early Childhood to Adolescence in a Cohort of 152 Children with Autism Spectrum Disorders
Developmental Trajectories of Adaptive Behaviors from Early Childhood to Adolescence in a Cohort of 152 Children with Autism Spectrum Disorders
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DOI：
10.1007/s10803-011-1357-z
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发表时间：
2012-07-01
影响因子：
3.9
通讯作者：
Pry, Rene
中科院分区：
文献类型：
--
作者：
Baghdadli, Amaria;Assouline, Brigitte;Pry, Rene
本研究调查了152名儿童近10年期间的变化(T1: 4.9（+/- 1.3）岁；T2: 8.1（+/- 1.3）年；T3: 15（+/- 1.6）年)，采用基于群体的半参数方法，以确定不同的发展轨迹。自闭症谱系障碍儿童的适应能力在青春期仍然存在重要缺陷，但适应技能的变化表现出两种不同的增长速度。单变量分析显示，社交和沟通结果的低增长轨迹与5岁时的以下特征有关：认知和语言技能低下、癫痫的存在和自闭症的严重程度。多变量分析证实，5岁时的风险因素是语言能力低下和自闭症严重程度对10年后的社交和沟通结果都有影响，而几个小时的早期干预是沟通的保护因素。
This study examines change in 152 children over an almost 10-year period (T1: 4.9 (+/- 1.3) years; T2: 8.1 (+/- 1.3) years; T3: 15(+/- 1.6) years) using a group-based, semi-parametric method in order to identify distinct developmental trajectories. Important deficits remain at adolescence in the adaptive abilities of children with Autism spectrum disorders, but changes in adaptive skills show two distinct growth rates. The univariate analysis reveals that low growth trajectories for both social and communication outcome are associated with the following characteristics at age 5: low cognitive and language skills, presence of epilepsy, and severity of autism. The multivariate analysis confirms that risk factors at age 5, were low language and severity of autism for both social and communication outcomes 10 years later, and that hours of early intervention was protective factor for communication.