Microneedles: A New Frontier in Nanomedicine Delivery.
Microneedles: A New Frontier in Nanomedicine Delivery.
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DOI：
10.1007/s11095-016-1885-5
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发表时间：
2016-05
影响因子：
3.7
通讯作者：
Donnelly RF
中科院分区：
文献类型：
--
作者：
Larrañeta E;McCrudden MT;Courtenay AJ;Donnelly RF
本综述旨在简明扼要地描绘两个单独研究领域的发展，即纳米医学，特别强调纳米颗粒（NP）和微粒（MP），以及微针（MN）技术，这些技术最近已被用于组合方法中，以在皮肤上有效输送各种药物。这是透皮给药领域药物科学研究的一个新兴且令人兴奋的领域，因此毫无疑问将随着颗粒和微纳米颗粒新配方和制造方法的出现而继续发展。首先，概述了皮肤结构和结构的基本方面，特别是它们对 NP 和 MP 渗透的影响。接下来，描述了各种不同的粒子，以及目前正在开发的各种 MN 模式。这篇综述最后强调了一些文献中描述的利用这两种方法的新型递送系统，并引导读者了解纳米药物与 MN 相结合的新兴用途。
This review aims to concisely chart the development of two individual research fields, namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles (MP), and microneedle (MN) technologies, which have, in the recent past, been exploited in combinatorial approaches for the efficient delivery of a variety of medicinal agents across the skin. This is an emerging and exciting area of pharmaceutical sciences research within the remit of transdermal drug delivery and as such will undoubtedly continue to grow with the emergence of new formulation and fabrication methodologies for particles and MN. Firstly, the fundamental aspects of skin architecture and structure are outlined, with particular reference to their influence on NP and MP penetration. Following on from this, a variety of different particles are described, as are the diverse range of MN modalities currently under development. The review concludes by highlighting some of the novel delivery systems which have been described in the literature exploiting these two approaches and directs the reader towards emerging uses for nanomedicines in combination with MN.