Effect of cimetidine on basal and histamine-induced secretion of parathyroid hormone in vitro.
Effect of cimetidine on basal and histamine-induced secretion of parathyroid hormone in vitro.
复制标题
西咪替丁对体外甲状旁腺激素基础和组胺诱导分泌的影响。
作者：
P. Wagner;U. Krause;T. Schärfe;J. Beyer;M. Rothmund
使用从（a）原发性甲状旁腺腺瘤和（B）接受慢性血液透析患者的继发性增生性甲状旁腺组织中获得的单细胞悬液检测西咪替丁对基础和组胺诱导的PTH分泌的影响。组胺刺激的激素分泌呈剂量依赖性。西咪替丁抑制基础和组胺刺激的激素分泌。在治疗范围内，对腺瘤和增生的抑制效果相同。腺瘤和继发性增生腺体均表现出组胺H2受体相关反应。组胺在甲状旁腺功能亢进症发病机制中的作用尚不十分清楚，因此西咪替丁用于原发性和继发性甲状旁腺功能亢进症的药物治疗的可能益处必须通过仔细的临床试验来证明。
The effect of cimetidine on basal and histamine-induced PTH secretion was tested using single cell suspensions obtained from (a) primary parathyroid adenomas, and (b) secondary hyperplastic parathyroid tissue from patients undergoing chronic hemodialysis. The histamine-stimulated hormone secretion was dose-dependent. Cimetidine suppressed both basal and histamine-stimulated hormone secretion. Within the therapeutic range the suppressive effect was identical for adenoma and hyperplasia. Both adenomata and secondary hyperplastic glands showed a histamine H2-receptor-related response. The role of histamine in the pathogenesis of hyperparathyroidism is not quite clear so that the possible benefits of cimetidine for medical treatment of primary and secondary hyperparathyroidism will have to be proven by careful clinical trials.