The role of autophagy in liver diseases: mechanisms and potential therapeutic targets.
The role of autophagy in liver diseases: mechanisms and potential therapeutic targets.
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DOI：
10.1155/2015/480508
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发表时间：
2015
影响因子：
--
通讯作者：
Shen HM
中科院分区：
文献类型：
--
作者：
Cursio R;Colosetti P;Codogno P;Cuervo AM;Shen HM
自噬，或细胞自我消化，是一个精心策划的细胞途径，对细胞的发育，分化，稳态和存活至关重要。自噬过程用于消除不需要的蛋白质和受损的细胞器，并去除细胞内的微生物病原体。正常肝功能需要肝细胞基础自噬。事实上，由于其高生物合成活性以及在蛋白质周转和碳水化合物储存中的作用，肝细胞可能特别依赖于基础自噬来维持其正常生理功能。自噬似乎不仅在正常的肝脏生理中起重要作用，而且在肝脏疾病的发病机制中起重要作用，如非酒精性和酒精性脂肪肝、药物诱导的肝损伤、蛋白质构象肝病、病毒性肝炎、纤维化、衰老、肝癌和肝脏缺血再灌注损伤。
Autophagy, or cellular self-digestion, is an orchestrated cellular pathway crucial for development, differentiation, homeostasis, and survival of cells. The autophagic process is used to eliminate unwanted proteins and damaged organelles and to remove intracellular microbial pathogens. Normal liver function requires hepatocellular basal autophagy. In fact, due to their high biosynthetic activity and role in protein turnover and carbohydrate storage, hepatocytes may be particularly dependent on basal autophagy for their normal physiological functions.Autophagy seems to play an important role not only in normal liver physiology, but also in the pathogenesis of liver diseases such as nonalcoholic and alcoholic fatty liver, druginduced liver injury, protein conformational liver diseases, viral hepatitis, fibrosis, aging, liver cancer, and liver ischemiareperfusion injury.