SPATIAL RECOGNITION AND SPATIAL ORDER MEMORY IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE
SPATIAL RECOGNITION AND SPATIAL ORDER MEMORY IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE
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DOI：
10.1016/0028-3932(92)90014-d
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发表时间：
1992-01-01
期刊：
影响因子：
2.6
通讯作者：
STRASSBERG, DS
中科院分区：
文献类型：
--
作者：
ADELSTEIN, TB;KESNER, RP;STRASSBERG, DS
被诊断为患有轻度或中度阿尔茨海默型原发性退行性痴呆（PDDAT）的患者和正常老年受试者进行了空间顺序和空间识别记忆测试。空间顺序记忆的结果表明，与正常老年人相比，轻度PDDAT患者仅对最后一个序列位置表现出记忆受损。相比之下，在空间识别记忆方面，轻度PDDAT患者仅对早期序列位置表现出记忆受损。中度PDDAT患者的空间顺序和空间识别记忆在所有序列位置上均受损。基于在海马和顶叶皮质病变的动物和患者中观察到的可比缺陷模式，这表明PDDAT患者显示的记忆缺陷可能是海马和顶叶皮质中潜在病理学的功能。
Patients diagnosed as having mild or moderate primary degenerative dementia of the Alzheimer's type (PDDAT), and normal elderly subjects were tested for spatial order and a spatial recognition memory. Results for spatial order memory indicated that compared to normal elderly subjects, patients with mild PDDAT showed an impaired memory only for the last serial positions. In contrast, with respect to spatial recognition memory, patients with mild PDDAT showed an impaired memory only for the early serial positions. Patients with moderate PDDAT were impaired on all serial positions for both spatial order and spatial recognition memory. Based on comparable deficit patterns seen in animals and patients with hippocampal and parietal cortex lesions, it is suggested that memory deficits displayed by PDDAT patients might be a function of underlying pathology in the hippocampus and parietal cortex.