A quantitative study of the response to adenosine triphosphate of the blood vessels of the human hand and forearm
A quantitative study of the response to adenosine triphosphate of the blood vessels of the human hand and forearm
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人手和前臂血管对三磷酸腺苷反应的定量研究
DOI：
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发表时间：
1954
期刊：
影响因子：
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通讯作者：
J. Shepherd
中科院分区：
文献类型：
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作者：
F. Duff;G. C. Patterson;J. Shepherd
达夫，格林菲尔德，谢泼德和汤普森(1953)对乙酰胆碱和组胺对前臂和手部血管的影响进行了定量测量。本文描述了使用三磷酸腺苷(ATP)的类似观察，并将其血管扩张特性与乙酰胆碱和组胺的特性进行了比较；这一信息是另一项研究所必需的。三磷酸腺苷对循环的影响是有趣的，因为有人认为这种物质或其衍生物可能在运动(Zipf，1931 a；Rigler，1932)、循环停止(Zipf，1931 a)和创伤性休克(Bennet&Drury，1931；Zipf，1931 b；Green，1943)之后的循环变化中发挥作用。人体动脉内注射三磷酸腺苷已被证明会导致前臂皮肤红斑和温度升高(Stoner&Green，1945)，并增加手指体积(Davies，Gropper&Schroeder，1951)。然而，关于三磷酸腺苷对人体肢体血管影响的详细测量尚未发现。由于有证据表明横纹肌中的三磷酸腺苷以这种形式存在(Bielschowsky&Green，1944)，所以本研究使用了镁盐(MgATP)。并用钠盐进行了试验，并与镁盐进行了比较。
Quantitative measurements of the effects of acetylcholine and histamine on the forearm and hand blood vessels have been made by Duff, Greenfield, Shepherd & Thompson (1953). This paper describes similar observations using adenosine triphosphate (ATP), and its vasodilator properties are compared with those of acetylcholine and histamine; this information was required for another investigation. The effects of adenosine triphosphate on the circulation are of interest as it has been suggested that this substance or its derivatives may play a part in the circulatory changes which follow exercise (Zipf, 1931 a; Rigler, 1932), circulatory arrest (Zipf, 1931 a) and traumatic shock (Bennet & Drury, 1931; Zipf, 1931 b; Green, 1943). The intra-arterial injection ofATP in man has been shown to cause an erythema and rise in temperature of the forearm skin (Stoner & Green, 1945), and an increase in finger volume (Davies, Gropper & Schroeder, 1951). Detailed measurements of the effects of ATP on the limb vessels in man, however, have not been found. The magnesium salt (MgATP) was used for the present investigation as there is some evidence that the ATP in striated muscle is present in this form (Bielschowsky & Green, 1944). The sodium salt was also used in some experiments and its effects are compared with those of the magnesium salt.