Hair: a diagnostic tool to complement blood serum and urine.
Hair: a diagnostic tool to complement blood serum and urine.
复制标题
头发：补充血清和尿液的诊断工具。
DOI：
10.1126/science.725602
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发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
T. Maugh
中科院分区：
文献类型：
--
作者：
T. Maugh
头发有可能成为一种可标记的诊断工具。它很容易收集，不会对供体造成创伤，可以储存而不会变质，并且其内容物可以相对容易地进行分析。特别是微量元素，在头发中的积累浓度通常至少比血清或尿液中的浓度高10倍，并可提供营养状况和暴露于重金属污染物的连续记录。一些药物已经被证明会在头发中积累，当足够精确的分析技术发展起来时，似乎有可能在头发中发现其他有机化学物质。因此，毛发分析有望成为血清和尿液分析作为诊断工具的理想补充。早期的研究者希望通过测量头发中100到15种微量元素的浓度，可以将从犯罪现场获得的头发样本与特定的个人联系起来。随后的工作表明，头发分析具有有限的法医学价值;从头部不同部位收集的头发中微量元素浓度的分布差异显着，并且许多头发的分布随时间而明显变化。在这个过程中，调查人员发现，
Hair has the potential to become a re-markable diagnostic tool. It is easily collected without trauma on the part of the donor, it can be stored without deterioration, and its contents can be analyzed relatively easily. Trace elements, in par-ticular, are accumulated in hair at con-centrations that are generally at least ten times higher than those present in blood serum or urine and may provide a contin-uous record of nutritional status and exposure to heavy metal pollutants. Some drugs have already been shown to accumulate in hair, and it seems likely that other organic chemicals may be identified there when sufficiently accurate ana-lytical techniques are developed. Hair analysis thus promises to be an ideal complement to serum and urine analysis as a diagnostic tool.Much of the original interest in analy-sis of hair involved its application to forensic science. Early investigators hoped that measurement of the concentrations of 10to 15 trace elements in hair might make it possible to link a hair sample obtained at the scene ofa crime with a spe-cific individual. Subsequent work has shown that hair analysis has limitedforensic value; profiles of trace element concentrations vary significantly in hairs collected from different parts of the head, and profiles obtained with many hairs change appreciably with time. In the process, though, investigators found