Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women
Exposure to Organophosphate Pesticides and Menstrual Cycle Characteristics in Chinese Preconceptional Women
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中国孕前妇女有机磷农药暴露与月经周期特征
DOI：
10.1093/aje/kwz242
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发表时间：
2020
影响因子：
5
通讯作者：
Tian Ying
中科院分区：
文献类型：
--
作者：
Zhang Yan;Ji Lin;Hu Yi;Tse Lap Ah;Wang Yiwen;Qin Kaili;Ding Guodong;Zhou Yijun;Yu Xiaodan;Ouyang Fengxiu;Zhang Jun;Gao Yu;Tian Ying
有机磷是中国使用最多的农药。中国人群，包括怀孕前的女性，受到高度暴露，但人们对OP暴露与人类月经之间的联系知之甚少。我们对准备怀孕的妇女进行了横断面分析，以调查暴露于OP的生物标志物与月经周期特征之间的关系。从2013年到2015年，上海两家妇产医院的627名妇女免费前往孕前保健诊所就诊，中国。通过问卷调查获得有关月经周期特征的信息。通过测量尿中6种二烷基磷酸盐代谢物(二甲基磷酸盐、二甲基硫代磷酸盐、二甲基二硫代磷酸盐、二乙基磷酸盐、二乙基硫代磷酸盐和二乙基二硫代磷酸盐)的浓度来评估OP暴露。用多元线性回归模型和Logistic回归模型分析二烷基磷酸代谢产物浓度与月经周期特征的关系。对数转换后的磷酸二乙酯代谢产物水平(磷酸二乙酯和硫代磷酸二乙酯的总和)与月经周期不规律的更高风险相关(调整后的优势比=22.36，95%可信区间：1.28，4.34)。磷酸二乙酯代谢产物浓度较高(对数转换)的受试者月经出血持续时间较短(调整后的β=−0.33，95%可信区间：−0.64，−0.02)。这些发现表明，OP暴露可能与未孕妇女月经功能的改变有关。
Organophosphates (OPs) are the most heavily used pesticides in China. The Chinese population, including preconceptional women, is highly exposed, yet little is known regarding the associations between OP exposure and menstruation in humans. We conducted a cross-sectional analysis in women preparing for pregnancy to investigate the relationship between biomarkers of OP exposure and menstrual cycle characteristics. From 2013 to 2015, 627 women visiting free preconception-care clinics at 2 maternity hospitals in Shanghai, China, were included. Information on menstrual cycle characteristics was obtained through questionnaires. OP exposure was assessed by measuring urine concentrations of 6 dialkylphosphate metabolites (dimethylphosphate, dimethylthiophosphate, dimethyldithiophosphate, diethylphosphate, diethylthiophosphate, and diethyldithiophosphate). The relationship between concentrations of dialkylphosphate metabolites and menstrual cycle characteristics was analyzed using multiple linear regression models and logistic regression models. Log-transformed levels of diethyl phosphate metabolites (the sum of diethylphosphate and diethylthiophosphate levels) were related to a higher risk of irregularity of menstrual cycles (adjusted odds ratio = 2.36, 95% confidence interval: 1.28, 4.34). Subjects with a higher concentration of diethyl phosphate metabolites (log-transformed) had a shorter duration of menstrual bleeding (adjusted β = −0.33, 95% confidence interval: −0.64, −0.02). The findings suggest that OP exposure may be associated with alterations in menstrual function in preconceptional women.