Conditioned responses to a taste conditioned stimulus paired with lithium chloride administration.

Conditioned responses to a taste conditioned stimulus paired with lithium chloride administration.
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对味觉条件刺激的条件反应与氯化锂给药相结合。

DOI:
10.1037//0735-7044.104.5.711
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发表时间:
1990
影响因子:
1.9
通讯作者:
Bernstein,IL
Bernstein,IL
中科院分区:
医学4区
文献类型:
--
作者:
Meachum,CL;Bernstein,IL

文献摘要

被引文献

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本实验研究了行为条件反射(CR)是否发展到氯化锂(LiCl)配对的味道,以及这些CR是否类似于给药后的行为。大鼠暴露于糖精溶液,通过口内输注,然后注射氯化锂或生理盐水。当单独递送糖精条件刺激时,在条件化后评估CR。对LiCl输送的无条件反应是一种非常独特的姿势,被称为“趴在肚子上”。本研究表明,这种行为模式也发生后交付的氯化锂配对的味道解决方案。这些非条件性行为和条件性行为之间的相似性与以下假设一致:味觉厌恶习得期间的反应是条件性的,并且CR与条件反射中使用的药物产生的CR相似。
The present experiments examined whether behavioral conditioned responses (CRs) develop to lithium chloride (LiCl)–paired tastes and whether these CRs are similar to the behaviors that follow administration of the drug. Rats were exposed to a saccharin solution via intraoral infusions before being injected with either LiCl or saline. CRs were assessed after conditioning when the saccharin conditioned stimulus was delivered alone. The unconditioned response to LiCl delivery is a very distinctive posture that has been termed “lying-on-belly.” The present study indicates that this behavior pattern also occurs after the delivery of a LiCl-paired taste solution. The similarity between these unconditioned and conditioned behaviors is consistent with the hypothesis that responses are conditioned during taste aversion acquisition and that CRs are similar to those that are generated by the drugs used in conditioning.