Naloxone has a direct effect on the adrenal cortex.
Naloxone has a direct effect on the adrenal cortex.
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DOI：
10.1210/endo-109-4-1132
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发表时间：
1981-10
期刊：
影响因子：
4.8
通讯作者：
J. Lymangrover;L. Dokas;A. Kong;R. Martín;M. Saffran
中科院分区：
文献类型：
--
作者：
J. Lymangrover;L. Dokas;A. Kong;R. Martín;M. Saffran
本文观察了纳洛酮对大鼠肾上腺皮质组织皮质酮分泌的影响。高剂量（10-3和10- 4 M）的纳洛酮产生的基础类固醇合成下降，而较低剂量（10-5-10-7 M）的纳洛酮导致皮质酮分泌升高。同时加入等份的ACTH和不同量的纳洛酮导致组织对ACTH的类固醇反应发生剂量依赖性改变。使用较高剂量（10-3和10-4 M）的纳洛酮时，对初始剂量ACTH的反应几乎没有或没有显著变化;然而，在单次等分纳洛酮给药后2小时和4小时，对ACTH的类固醇生成反应显著增强。较低剂量的纳洛酮（10-610-10 M）仅导致初始ACTH反应增强。ACTH与10-12 M纳洛酮同时给药，在本研究的任何时期对ACTH的反应均无明显改变。
The effects of naloxone on basal and ACTHstimulated corticosterone secretion from superfused rat adrenocortical tissue were investigated. High doses (10-3 and 10-4M) of naloxone produced a decline in basal steroidogenesis, whereas lower doses (10-5-10-7 M) of naloxone resulted in elevations of corticosterone secretion. The simultaneous addition of an aliquot of ACTH and varying amounts of naloxone resulted in a dose-dependent alteration in the steroidgenic response by the tissue to ACTH. With higher doses (10-3 and 10-4 M) of naloxone, there were little or no significant alterations in the response to an initial dose of ACTH; however, the steroidogenic responses to ACTH administered 2 and 4 h after the single aliquot of naloxone were significantly potentiated. The lower dose of naloxone (10-610-10 M) resulted only in the potentiation of the initial ACTH response. The simultaneous administration of ACTH and 10-12 M naloxone resulted in no apparent alteration in the response to ACTH at any period in the stu...