Reconstruction of canine mandibular bone defects using a bone transport reconstruction plate.
Reconstruction of canine mandibular bone defects using a bone transport reconstruction plate.
复制标题
使用骨转运重建板重建犬下颌骨缺损。
DOI：
10.1097/sap.0b013e31818d130c
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发表时间：
2009-10
影响因子：
1.5
通讯作者：
Opperman LA
中科院分区：
文献类型：
--
作者：
Elsalanty ME;Zakhary I;Akeel S;Benson B;Mulone T;Triplett GR;Opperman LA
下颌骨节段性骨缺损的重建是一项具有挑战性的任务。本研究测试了一种基于骨运输牵引成骨原理的用于重建下颌骨缺损的新装置。十三只比格犬被分为对照组和实验组。在所有动物的下颌骨一侧均产生 3 厘米的缺损。在八只对照动物中，用重建板稳定缺损而无需进一步重建，并在手术后两到三个月处死动物。其余五只动物用骨运输重建板（BTRP）重建，该骨运输重建板包括带有口腔内运输单元的重建板，并在巩固一个月后处死。临床评估、锥束 CT 密度测定、三维组织形态测定和对接部位组织学显示，在分散组的缺损内有显着的新骨形成。新骨的物理尺寸和结构参数与对侧正常骨相当。对接部位的骨结合仍然是一个问题。
Reconstruction of mandibular segmental bone defects is a challenging task. This study tests a new device used for reconstructing mandibular defects based on the principle of bone transport distraction osteogenesis. Thirteen beagle dogs were divided into control and experimental groups. In all animals, a 3 cm defect was created on one side of the mandible. In eight control animals, the defect was stabilized with a reconstruction plate without further reconstruction and the animals were sacrificed two to three months after surgery. The remaining five animals were reconstructed with a bone transport reconstruction plate (BTRP), comprising a reconstruction plate with attached intraoral transport unit, and were sacrificed after one month of consolidation. Clinical evaluation, cone-beam CT densitometry, three-dimensional histomorphometry, and docking site histology revealed significant new bone formation within the defect in the distracted group. The physical dimensions and architectural parameters of the new bone were comparable to the contralateral normal bone. Bone union at the docking site remains a problem.