White matter changes in dementia: does radiology matter?
White matter changes in dementia: does radiology matter?
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DOI：
10.1259/bjr/35265137
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Wahlund, L-O
中科院分区：
文献类型：
--
作者：
Bronge, L.;Wahlund, L-O
脑白质改变常见于老年患者的MRI。这些变化的意义仍存在争议。脑白质改变的来源是不同的，但大多数是由于脑血管的动脉硬化。与痴呆症相关的脑白质改变的临床后果仍不清楚。然而，最近许多研究发现，白质改变的程度和认知功能障碍的存在之间存在联系。这在血管性痴呆症中最为明显，但也被认为在阿尔茨海默病中也很重要。在这篇综述中，我们讨论了这些变化的背景以及它们与认知障碍相关的临床后果。
White matter changes are frequently seen on MRI in elderly patients. The significance of these changes is still debated. The origin of white matter changes is heterogeneous but the majority are due to arteriosclerosis in brain vessels. The clinical consequence of the presence of white matter changes in relation to dementia is still unclear. Lately, however, many studies have found a relation between the presence and the degree of white matter changes and cognitive dysfunction. This is most obvious in vascular dementia, but has also been suggested to be of importance in Alzheimer's disease. In this review we discuss the background of these changes and the clinical consequences of them in relation to cognitive disorders.