Role of fluid dynamics and inflammation in intracranial aneurysm formation.
Role of fluid dynamics and inflammation in intracranial aneurysm formation.
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DOI：
10.1161/circulationaha.113.001444
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发表时间：
2014-01-21
期刊：
影响因子：
37.8
通讯作者：
Edelman ER
中科院分区：
文献类型：
--
作者：
Turjman AS;Turjman F;Edelman ER
炎症作为动脉瘤发生的关键介质的出现为了解颅内动脉瘤（IA）的潜在发展过程提供了新的机会。炎症统一了局部流动、壁的机械性质和生化介质的改变的三联影响，并为构建强大的预测工具开辟了新的途径。这篇综述讨论了颅内动脉瘤形成过程中炎症级联反应的影响，以及其相关的形态、结构和机械变化，特别是在血流诱导的内皮功能障碍的情况下。
The emergence of inflammation as a key mediator of aneurysmogenesis provides new opportunities to understand the processes underlying development of intracranial aneurysms (IA). Inflammation unifies the triptych influences of alterations in local flow, mechanical properties of the wall and biochemical mediators and opens new avenues for building robust predictive tools. This review discusses the impact of the inflammatory cascade during the formation of intracranial aneurysms, and its associated morphological, structural and mechanical changes especially in the setting of flow-induced endothelial dysfunction.