Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
Indirect optical trapping using light driven micro-rotors for reconfigurable hydrodynamic manipulation
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DOI：
10.1038/s41467-019-08968-7
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发表时间：
2019-03-14
影响因子：
16.6
通讯作者：
Phillips, David B.
中科院分区：
文献类型：
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作者：
Butaite, Une G.;Gibson, Graham M.;Phillips, David B.
光镊是一种多用途的工具，用于探索介观世界，允许非接触式操纵纳米级物体。然而，用强激光直接照射限制了它们与活生物标本的使用，并限制了可以捕获的材料类型。在这里，我们展示了一种间接的光学捕获平台，它通过使用水动力对水性颗粒施加纳米级精度的控制来规避这些限制，而不直接照射它们。我们的概念是基于光学驱动的微型机器人：闭环控制，使高度局部化的流场被精确地引导光学捕获的微型转子的运动来塑造。我们展示了不能直接光学捕获的吸收颗粒的2D捕获，稳定酵母细胞的位置和方向，并同时展示了对多个对象的独立控制。我们的工作扩展了光镊平台的能力，并代表了一个新的范例，操纵水介观系统。
Optical tweezers are a highly versatile tool for exploration of the mesoscopic world, permitting non-contact manipulation of nanoscale objects. However, direct illumination with intense lasers restricts their use with live biological specimens, and limits the types of materials that can be trapped. Here we demonstrate an indirect optical trapping platform which circumvents these limitations by using hydrodynamic forces to exert nanoscale-precision control over aqueous particles, without directly illuminating them. Our concept is based on optically actuated micro-robotics: closed-loop control enables highly localised flow-fields to be sculpted by precisely piloting the motion of optically-trapped micro-rotors. We demonstrate 2D trapping of absorbing particles which cannot be directly optically trapped, stabilise the position and orientation of yeast cells, and demonstrate independent control over multiple objects simultaneously. Our work expands the capabilities of optical tweezers platforms, and represents a new paradigm for manipulation of aqueous mesoscopic systems.