Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia
Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia
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DOI：
10.1016/j.beha.2010.08.002
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发表时间：
2010-09-01
影响因子：
2.1
通讯作者：
Meijerink, Jules P. P.
中科院分区：
文献类型：
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作者：
Meijerink, Jules P. P.
相互排斥的致癌重排可能描绘出特定的t细胞急性淋巴细胞白血病（T-ALL）亚群，到目前为止，至少已经确定了4个分子细胞遗传学亚群，即TAL/LMO， TLX1/HOX11， TLX3/HOX11L2和HOXA亚群。第五组具有不成熟的免疫表型，可以通过早期t细胞前体标记来预测，并且与不良预后相关。这些亚群与反映特定t细胞发育阶段阻滞的特定免疫表型标志物表达的关联将被回顾。这些强烈的相关性迫切需要广泛研究与未来治疗方案结果相关的致癌重排和免疫表型标记物，无论是对儿童还是成人T-ALL患者。(C) 2010 Elsevier Ltd.版权所有。
Mutually exclusive oncogenic rearrangements may delineate specific T-cell acute lymphoblastic leukaemia (T-ALL) subgroups, and so far at least 4 molecular-cytogenetic subgroups have been identified, i.e. the TAL/LMO, the TLX1/HOX11, the TLX3/HOX11L2 and the HOXA subgroups. A fifth group with an immature immunophenotype that can be predicted by an early T-cell precursor signature has also been identified, and has been associated with poor outcome. The association of these subgroups with the expression of specific immunophenotypic markers reflecting arrest at specific T-cell developmental stages will be reviewed. These strong associations urge the need to extensively study oncogenic rearrangements and immunophenotypic markers in relation to outcome for future treatment protocols, both for paediatric as well as adult T-ALL patients. (C) 2010 Elsevier Ltd. All rights reserved.