Enrolment and baseline characteristics in the WHO Multicentre Growth Reference Study
Enrolment and baseline characteristics in the WHO Multicentre Growth Reference Study
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DOI：
10.1080/08035320500495407
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发表时间：
2006-04-01
期刊：
影响因子：
3.8
通讯作者：
Heinig, M. Jane
中科院分区：
文献类型：
--
作者：
de Onis, Mercedes;Onyango, Adelheid;Heinig, M. Jane
目的：描述 WHO 多中心生长参考研究 (MGRS) 样本的筛选、招募、合规性、样本保留和基线特征。方法：一项以社区为基础的多国研究，将出生至 24 个月的纵向随访与 18 至 71 个月儿童的横断面调查相结合。研究亚群必须具有有利于生长的社会经济条件、低流动性以及 >= 20% 的母亲实行母乳喂养。个体纳入标准是没有已知的生长环境限制、遵守 MGRS 喂养建议、母亲不吸烟、单足月出生以及无明显发病率。对于纵向样本，母亲和新生儿在出生时接受筛查和登记，并在 24 个月之前在家中进行了 21 次探访。结果：在纵向成分筛查的 13 741 名受试者中，约 83% 不符合资格，5% 拒绝参加。在巴西、加纳、印度和阿曼，社会经济地位低下是不参加的主要原因，而在挪威和美国，父母的拒绝是不参加的主要原因。总体而言，88.5% 的入组受试者完成了 24 个月的随访，其中 51% (888) 遵守 MGRS 喂养和禁止吸烟标准。对于横截面成分，21 510 名筛选受试者中的 69% 因与纵向成分类似的原因而被排除。尽管低出生体重不是排除标准，但其患病率较低（纵向和横向样本分别为 2.1% 和 3.2%）。父母受教育程度较高，平均受教育程度在14至15岁之间。
Aim: To describe the WHO Multicentre Growth Reference Study (MGRS) sample with regard to screening, recruitment, compliance, sample retention and baseline characteristics. Methods: A multi-country community-based study combining a longitudinal follow-up from birth to 24 mo with a cross-sectional survey of children aged 18 to 71 mo. Study subpopulations had to have socio-economic conditions favourable to growth, low mobility and >= 20% of mothers practising breastfeeding. Individual inclusion criteria were no known environmental constraints on growth, adherence to MGRS feeding recommendations, no maternal smoking, single term birth and no significant morbidity. For the longitudinal sample, mothers and newborns were screened and enrolled at birth and visited 21 times at home until age 24 mo. Results: About 83% of 13 741 subjects screened for the longitudinal component were ineligible and 5% refused to participate. Low socioeconomic status was the predominant reason for ineligibility in Brazil, Ghana, India and Oman, while parental refusal was the main reason for non-participation in Norway and USA. Overall, 88.5% of enrolled subjects completed the 24-mo follow-up, and 51% (888) complied with the MGRS feeding and no-smoking criteria. For the cross-sectional component, 69% of 21 510 subjects screened were excluded for similar reasons as for the longitudinal component. Although low birthweight was not an exclusion criterion, its prevalence was low (2.1% and 3.2% in the longitudinal and cross-sectional samples, respectively). Parental education was high, between 14 and 15 y of education on average.