Elevated levels of interferon-γ, interleukin-10, interleukin-6 during active disease in Indian kala azar
Elevated levels of interferon-γ, interleukin-10, interleukin-6 during active disease in Indian kala azar
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DOI：
10.1016/j.clim.2006.01.017
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发表时间：
2006-06-01
影响因子：
8.6
通讯作者：
Salotra, Poonam
中科院分区：
文献类型：
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作者：
Ansari, Nasim Akhtar;Saluja, Sumita;Salotra, Poonam
我们使用细胞珠阵列技术评估了 35 名黑热病 (KA) 患者、29 名黑热病后皮肤利什曼病 (PKDL) 和 18 名健康对照者血清中 6 种细胞因子的水平。结果表明，在活动性 KA 期间，干扰素 γ (IFN-gamma)、白细胞介素 (IL)-10 和 IL-6 水平显着升高，白色肿瘤坏死因子 α (TNF-α)、IL-2 和 IL-4 水平极低。 PKDL 中细胞因子的血清水平与对照相当，与 KA 或对照相比，白色 TNF-α 显着升高。治疗后阶段，KA患者IFN-γ、IL-10、IL-6水平显着下降；然而，IL-6 仍显着高于对照水平。此外，儿童和成人细胞因子水平的比较显示，儿科病例中 IL-10 水平升高。与有反应的病例相比，SAG 无反应的病例显示 IFN-γ 水平显着升高。结果表明，在活动 KA 期间，1 型反应并未受到抑制，并表明对 1 型刺激无反应的可能性可能普遍存在。 (c) 2006 Elsevier Inc. 保留所有权利。
We have evaluated levels of 6 cytokines in sera of 35 patients of kala azar (KA), 29 post kala azar dermal leishmaniasis (PKDL), and 18 healthy controls using cytometric bead array technology. Results indicated significantly high levels of interferon gamma (IFN-gamma), interleukin (IL)-10, and IL-6 during active KA, white tumor necrosis factor alpha (TNF-alpha), IL-2, and IL-4 were minimal. Serum level of cytokines in PKDL was comparable to the controls white TNF-alpha was significantly elevated compared to KA or control. At post-treatment stage, KA patients showed a significant decrement in the levels of IFN-gamma, IL-10, and IL-6; however, IL-6 remained significantly elevated above control levels. Further, comparison of cytokine levels in children and adults revealed elevated level of IL-10 in pediatric cases. SAG unresponsive cases showed significantly elevated levels of IFN-gamma in comparison with the responsive cases. The results depict that type1 response is not depressed during active KA and suggest the possibility that unresponsiveness to type1 stimuli may prevail. (c) 2006 Elsevier Inc. All rights reserved.